@article {17806,
	title = {Silk Fibroin/Nano-CaP Bilayered scaffolds for Osteochondral Tissue Engineering},
	journal = {Key Engineering Materials},
	volume = {587},
	year = {2014},
	month = {2014-01-30 00:00:00},
	pages = {245},
	publisher = {Trans Tech Publications, Switzerland},
	abstract = {

In this study, bilayered silk and silk/nano-CaP scaffolds were developed for osteochondral (OC) tissue engineering. Aqueous silk solution (16 wt.\%) was used for preparation of the cartilage-like layer and, for generation of the silk/nano-CaP suspension and the bottom layer (CaP/Silk: 16 wt.\%). The scaffolds were formed by using salt-leaching/lyophilization approach. The scanning electron microscopy revealed that the both layers presented porous structure and integrated well. Micro-computed tomography images confirmed that the CaP phase was only retained in the silk/nano-CaP layer. The hydration degree and mechanical properties of the bilayered scaffold were comparable to the ones of each single layer. The apatite crystal formation was limited to the silk/nano-CaP layer, when soaking the scaffold in a simulated body fluid solution, which is a must for the application of the developed scaffolds in OC tissue engineering.

}, keywords = {Bilayered Scaffold, Nano Calcium Phosphate, Osteochondral Tissue Engineering, Silk Fibroin}, isbn = {978-3-03785-899-8}, issn = {1662-9795}, doi = {10.4028/www.scientific.net/KEM.587.245}, url = {http://www.ttp.net/978-3-03785-899-8.html}, author = {Yan, L. P. and Oliveira, J. M. and Oliveira, A. L. and Reis, R. L.} }

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