@article {18269,
	title = {Performance of biodegradable microcapsules of poly(butylene succinate), poly(butylene succinate-co-adipate) and poly(butylene terephthalate-co-adipate) as drug encapsulation systems},
	journal = {Colloids and Surfaces B: Biointerfaces},
	volume = {84},
	year = {2014},
	month = {2014-03-03 00:00:00},
	pages = {498{\textendash}507},
	abstract = {Poly(butylene succinate) (PBSu), poly(butylene succinate-co-adipate) (PBSA) and poly(butylene terephthalate-co-adipate) (PBTA) microcapsules were prepared by the double emulsion/solvent evap- oration method. The effect of polymer and poly(vinyl alcohol) (PVA) concentration on the microcapsule morphologies, drug encapsulation efficiency (EE) and drug loading (DL) of bovine serum albumin (BSA) and all-trans retinoic acid (atRA) were all investigated. As a result, the sizes of PBSu, PBSA and PBTA microcapsules were increased significantly by varying polymer concentrations from 6 to 9\%. atRA was encapsulated into the microcapsules with an high level of approximately 95\% EE. The highest EE and DL of BSA were observed at 1\% polymer concentration in values of 60 and 37\%, respectively. 4\% PVA was found as the optimum concentration and resulted in 75\% EE and 14\% DL of BSA. The BSA release from the capsules of PBSA was the longest, with 10\% release in the first day and a steady release of 17\% until the end of day 28. The release of atRA from PBSu microcapsules showed a zero-order profile for 2 weeks, keeping a steady release rate during 4 weeks with a 9\% cumulative release. Similarly, the PBSA micro- capsules showed a prolonged and a steady release of atRA during 6 weeks with 12\% release. In the case of PBTA microcapsules, after a burst release of 10\% in the first day, showed a parabolic release profile of atRA during 42 days, releasing 36\% of atRA.},
	keywords = {Controlled drug release Microcapsule, Poly(butylene succinate), Poly(butylene succinate-co-adipate), Poly(butylene terephthalate-co-adipate)},
	author = {Brunner, C. T. and Baran, E. T. and Pinho, E. D. and Reis, R. L. and Neves, N. M.}

Back to top