@article {18855,
	title = {Management of knee osteoarthritis. Current status and future trends.},
	journal = {Biotechnology and Bioengineering},
	year = {2016},
	month = {2016-10-05 00:00:00},
	pages = {1-23},
	publisher = {Wiley Periodicals, Inc.},
	abstract = {

Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2016;9999: 1-23. {\textcopyright} 2016 Wiley Periodicals, Inc.

}, keywords = {articular cartilage, Biomaterials, gene therapy, Osteoarthritis, regeneration, scaffolds, Tissue engineering, viscosupplementation}, issn = {2761-8194}, doi = {10.1002/bit.26182}, url = {http://onlinelibrary.wiley.com/doi/10.1002/bit.26182/abstract}, author = {Ondr{\'e}sik, M. and Maia, F. R. and da Silva Morais, A. and Gertrudes, A. and Bacelar, A. H. and Correia, C. and Gon{\c c}alves, C. and Radhouani, H. and Sousa, R.A. and Oliveira, J. M. and Reis, R. L.} }

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