@article {19118,
	title = {Bioplotting of a bioactive alginate dialdehyde-gelatin composite hydrogel containing bioactive glass nanoparticles.},
	journal = {Biofabrication},
	volume = {8},
	year = {2016},
	month = {2016-07-18 00:00:00},
	pages = {035005-8},
	publisher = {IOP Science},
	abstract = {

Alginate dialdehyde-gelatin (ADA-GEL) constructs incorporating bioactive glass nanoparticles (BGNPs) were produced by biofabrication to obtain a grid-like highly-hydrated composite. The material could induce the deposition of an apatite layer upon immersion in a biological-like environment to sustain cell attachment and proliferation. Composites were formulated with different concentrations of BGNPs synthetized from a sol-gel route, namely 0.1\% and 0.5\% (w/v). Strontium doped BGNPs were also used. EDS analysis suggested that the BGNPs loading promoted the growth of bone-like apatite layer on the surface when the constructs were immersed in a simulated body fluid. Moreover, the composite constructs could incorporate with high efficiency ibuprofen as a drug model. Furthermore, the biofabrication process allowed the successful incorporation of MG-63 cells into the composite material. Cells were distributed homogeneously within the hydrogel composite, and no differences were found in cell viability between ADA-GEL and the composite constructs, proving that the addition of BGNPs did not influence cell fate. Overall, the composite material showed potential for future applications in bone tissue engineering.

}, keywords = {ALGINATE, Bioactive glass Nanoparticles, bioactivity, biofabrication, bioplotting, composite, Gelatin}, issn = {1758-5090}, doi = {10.1088/1758-5090/8/3/035005}, url = {http://iopscience.iop.org/article/10.1088/1758-5090/8/3/035005/meta}, author = {Leite, A. J. and Sarker, B. and Zehnder, T. and Silva, R. and Mano, J. F. and Boccaccini, A. R.} }

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