Biomaterials, Biodegradables and Biomimetics Research Group

Conference Abstract -ISI Web of Science Indexed

Liquid marbles to culture adherent cells for high-throughput drug screening

Abstract

Liquid marbles (LM) are small liquid drops covered with hydrophobic powder (HP) particles. The hydrophobic shell prevents any direct contact between the liquid and surfaces outside the LM. LM can thus be easily manipulated and transferred, being candidates to be used as micro-biorreactors for distinct cells studies. Some applications for LM are tumor spheroids and embryoid bodies formation. The objective here was to develop a strategy to culture anchorage-depend cells in a liquid compartmented environment. For this we used poly (L-lactic acid) microparticles (lPLLAs) to provide the anchorage points for cells inside of the LM. The developed system shows high potential for high-throughput drug screening applications, focused on adherent cells.

Journal
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume
8
Edition
SI
Issue
1
Pagination
376
Publisher
WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
ISSN
1932-6254
URL
http://onlinelibrary.wiley.com/doi/10.1002/term.1932/abstract
Keywords
High-throughput screening, Hydrophobicity, Image processing, Lliquid marbles, Microbioreactors
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
SPECIAL
Year of Publication
2014
DOI
10.1002/term.1932
Date Published
2014-06-09
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