Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite

Abstract

This research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(epsilon-caprolactone) (*PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wet-spinning, were optimized. Stemming from a previous research activity on electrospinning of *PCL, *PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres' morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into *PCL fibrous mats. Fibres loaded with either CD or CD-HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental composition. Copyright (C) 2010 John Wiley & Sons, Ltd.

Journal
Journal of Tissue Engineering and Regenerative Medicine
Volume
5
Issue
4
Pagination
253-263
Publisher
WILEY-BLACKWELL
ISSN
1932-6254
URL
http://onlinelibrary.wiley.com/doi/10.1002/term.310/abstract
Keywords
bisphosphonates, Electrospinning, scaffolds, star polymers, Tissue engineering, wet-spinning
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Year of Publication
2011
DOI
10.1002/term.310
Date Published
2011-04-01
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