Biomaterials, Biodegradables and Biomimetics Research Group

Book Chapter

Progress in Dendrimer-Based Nanocarriers

Abstract

Dendrimers are one of the most useful drug/gene delivery systems. Their ability to be internalized and transfect cells without inducing toxicity and be tuned for stimuli-induced delivery confers a great advantage over other carriers namely viral vectors. Despite most of preclinical reports dealing with dendrimeric drug delivery systems have shown promising data, there is the need, however, to intensify the comprehensive research (in vitro and in vivo) for elucidating their stimuli-responsiveness, biodegradability, biocompatibility, biodistribution, and bioelimination. Future looks bright for dendrimer-based technologies in theranostics especially in cancer. Dendrimers as synthetic enzyme mimics are also most promising in tissue engineering applications and catalysis. Other interesting applications include their use as photoluminescent, photoelectric, and nonlinear optic materials.

Journal
Chapter 19 - Biomimetic Approaches for Biomaterials Development
Pagination
459-471
Publisher
WILEY-VCH Verlag
Keywords
Dendrimers, nanocarriers
Rights
Open Access
Peer Reviewed
Yes
Status
published
Year of Publication
2012
Date Published
2012-06-12
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