Biomaterials, Biodegradables and Biomimetics Research Group

Conference Abstract -ISI Web of Science Indexed

Surface controlled biomimetic coating of polycaprolactone nanofiber mesh architectures

Abstract

This work aims at developing novel electrospun nanofiber meshes coated with biomimetic calcium phosphate (BCP) mimicking the extracellular microenvironment found in the bone structure and not loosing the original morphology of the nanofibers. Poly(e-

caprolactone) (PCL) was selected because of its current use in medical applications, biodegradability, biocompatibility and sus- ceptibility to partial hydrolysis by alkaline treatments.

The deposition of a BCP layer, similar to the inorganic phase of bone, on PCL nanofiber meshes was achieved by a surface modi- fication. This initial surface modification was followed by treat- ments with solutions containing calcium and phosphate ions. The process was finished by the immersion in simulated body fluid (SBF) with 1.5

Journal
TISSUE ENGINEERING
Volume
13
Issue
7
Pagination
1759-1759
Keywords
biomimetic coating, electrospun nanofibers
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Year of Publication
2008
Date Published
2008-07-01
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