Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Tailored Freestanding Multilayered Membranes based on chitosan and Alginate

Abstract

Engineering metabolically demanding tissues requires the
supply of nutrients, oxygen, and removal of metabolic byproducts, as well
as adequate mechanical properties. In this work, we propose the
development of chitosan (CHIT)/alginate (ALG) freestanding membranes
fabricated by layer-by-layer (LbL) assembly. CHIT/ALG
membranes were cross-linked with genipin at a concentration of 1 mg·
mL−1 or 5 mg·mL−1. Mass transport properties of glucose and oxygen
were evaluated on the freestanding membranes. The diffusion of glucose
and oxygen decreases with increasing cross-linking concentration.
Mechanical properties were also evaluated in physiological-simulated
conditions. Increasing cross-linking density leads to an increase of storage
modulus, Young modulus, and ultimate tensile strength, but to a decrease in the maximum hydrostatic pressure. The in vitro
biological performance demonstrates that cross-linked films are more favorable for cell adhesion. This work demonstrates the
versatility and feasibility of LbL assembly to generate nanostructured constructs with tunable permeability, mechanical, and
biological properties.

Journal
Biomacromolecules
Volume
15
Pagination
3817-38-26
Publisher
ACS Publications
URL
http://pubs.acs.org/doi/abs/10.1021/bm501156v
Keywords
ALGINATE, Chitosan, diffusion
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
SupraRelax
Year of Publication
2014
DOI
10.1021/bm501156v
Date Published
2014-09-22
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