Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Unleashing the potential of supercritical fluids for polymer processing in tissue engineering and regenerative medicine

Abstract

One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to move from benchtop to bedside regards biomaterials development, despite the latest advances in polymer processing technologies.

A variety of scaffolds processing techniques have been developed and include solvent casting and particles leaching, compression molding and particle leaching, thermally induced phase separation, rapid prototyping, among others. Supercritical fluids appear as an interesting alternative to the conventional methods for processing biopolymers as they do not require the use of large amounts of organic solvents and the processes can be conducted at mild temperatures. However, this processing technique has only recently started to receive more attention from researchers. Different processing methods based on the use of supercritical carbon dioxide have been proposed for the creation of novel architectures based on natural and synthetic polymers and these will be unleashed in this paper.

Journal
The Journal of Supercritical Fluids
Volume
79
Pagination
177-185
Publisher
Elsevier
URL
http://www.sciencedirect.com/science/article/pii/S089684461300020X
Keywords
Biomaterials, foaming, natural polymers, phase inversion, scaffolds, supercritical fluids
Rights
Open Access
Peer Reviewed
Yes
Status
published
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