In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing

last updated: 2016-04-18
ProjectPOLARIS :: publications list
TitleIn vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing
Publication TypePapers in Scientific Journals
Year of Publication2016
AuthorsSantos L., Silva M., Gonçalves A. I., Pesqueira T., Rodrigues M. T., and Gomes M. E.
Abstract

Aim: To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth. Materials & methods: Magnetic biomaterials were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 and 3.6. Stem cell behavior was assessed in vitro and the inflammatory response, subcutaneously in Wistar rats. Results: Metabolic activity and proliferation increased significantly overtime in SPCL and magSPCL-1.8. Electromagnetic fields attenuated the presence of mast cells and macrophages in tissues surrounding SPCL and magSPCL-1.8, between weeks 1 and 9. Macrophage reduction was more pronounced for magSPCL-1.8, which could explain why this material prevented growth of fibrous tissue overtime. Conclusion: Magnetically actuated biomaterials have potential to modulate inflammation and the growth of fibrous tissue.

JournalNanomedicine
IssueRevolutionising Healthcare
Pagination1
Date Published2016-04-14
PublisherFuture Medicine
ISSN1743-5889
DOI10.2217/nnm-2015-0014
URLhttp://www.futuremedicine.com/doi/abs/10.2217/nnm-2015-0014
KeywordsFibrous adhesions, Magnetic biomaterials, Tendon healing/repair
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

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