|Project||POLARIS :: publications list|
|Title||In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing|
|Publication Type||Papers in Scientific Journals|
|Year of Publication||2016|
|Authors||Santos L., Silva M., Gonçalves A. I., Pesqueira T., Rodrigues M. T., and Gomes M. E.|
Aim: To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth. Materials & methods: Magnetic biomaterials were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 and 3.6. Stem cell behavior was assessed in vitro and the inflammatory response, subcutaneously in Wistar rats. Results: Metabolic activity and proliferation increased significantly overtime in SPCL and magSPCL-1.8. Electromagnetic fields attenuated the presence of mast cells and macrophages in tissues surrounding SPCL and magSPCL-1.8, between weeks 1 and 9. Macrophage reduction was more pronounced for magSPCL-1.8, which could explain why this material prevented growth of fibrous tissue overtime. Conclusion: Magnetically actuated biomaterials have potential to modulate inflammation and the growth of fibrous tissue.
|Keywords||Fibrous adhesions, Magnetic biomaterials, Tendon healing/repair|
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