Biomaterials, Biodegradables and Biomimetics Research Group

Book Chapter

Advanced in-vitro cell culture methods using natural biomaterials

Abstract

Abstract

The in vitro culturing of constructs for Tissue Engineering is a crucial step towards it future application in vivo. Not only the cells response to the biomaterials must be studied, but also the way cells interact with the scaffold in a specific tissue development context. In this chapter, we will provide an overview of the most advanced in vitro cell culture methods using natural-based biomaterials. We will explore the use of bioreactors as tools to scale-up biomaterials and cell-scaffold constructs, and also their use in the mimicking of a cellular microenvironment. The culture conditions of cells and scaffolds is another important issue, as different tissues require different oxygen tensions, or alternatively, show improved ability to regenerate when co-cultured with other types of cells. The recent advances in gene and drug delivery, using scaffolds and nanoparticles, are also explored herein.

Journal
Biomaterials from Nature for Advanced Devices and Therapies
Volume
1
Edition
1
Pagination
532 - 561
Publisher
Wiley
ISBN
978-1-118-47805-9
Keywords
Advanced Therapies, in vitro studies
Rights
Open Access
Peer Reviewed
Yes
Status
published
Project
MaxBone
Year of Publication
2016
Date Published
2016-10-01
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