@conference {15931,
	title = {In vivo Behaviour of Bonelike{\`O}/PLGA Hybrid: Histological Analysis and Peripheral Quantitative Computed Tomography (pQ-CT) Evaluation},
	journal = { Key Engineering Materials Vols. 254-256},
	year = {2007},
	month = {2007-03-16 00:00:00},
	pages = { 565-568},
	publisher = {Trans Tech Publications Ltd. },
	abstract = {

The present work consisted in assessing the in vivo biological behaviour of novel Bonelike/PLGA hybrid materials through subcutaneous and tibiae implantations for a 4 week period using an animal model. No sign of inflammation was observed as a result of subcutaneous implantation, which reveals that these materials were well-tolerated by the soft tissues. pQ-CT analysis demonstrated that the implanted materials were highly osteointegrated in bone tissue. SEM analysis at bone defect area revealed that Bonelike\ resorption occurred after 4 weeks of implantation. Although the osteoconductive properties of Bonelike\ have been reported in literature, the present work allowed to demonstrate that the silane-coupling agent and the PLGA treatments do not significantly modify the biological performance of Bonelike. This result is strongly encouraging since Bonelike/PLGA hybrid materials are being developed for bone tissue healing/regeneration purposes with simultaneous delivery of therapeuthic molecules.

}, keywords = {Bonelike, PQCT}, author = {Oliveira, J. M. and Lopes, M. A. and Kawai, T. and Ohtsuki, C. and Santos, J. and Afonso, A.} }

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