@article {18889,
	title = {Wetspun poly-L-(lactic acid)-borosilicate bioactive glass scaffolds for guided bone regeneration},
	journal = {Materials Science and Engineering: C},
	year = {2016},
	month = {2016-10-08 00:00:00},
	publisher = {Elsevier},
	abstract = {

We developed a porous Poly-L-Lactic Acid (PLLA) scaffold compounded with borosilicate bioactive glasses (BBGs) endowing it with bioactive properties. Porous PLLA-BBGs fibre mesh scaffolds were successfully prepared by the combination of wet spinning and fibre bonding techniques. Micro-computed tomography (μCT) confirmed that the PLLA-BBG scaffolds containing ≈\ 25\% of BBGs (w/w) exhibited randomly interconnected porous (58 to 62\% of interconnectivity and 53 to 67\% of porosity) with mean pore diameters higher that 100\ μm. Bioactivity and degradation studies were performed by immersing the scaffolds in simulated body fluid (SBF) and ultrapure water, respectively. The PLLA-BBG scaffolds presented a faster degradation rate with a constant release of inorganic species, which are capable to produce calcium phosphate structures at the surface of the material after 7\ days of immersion in SBF (Ca/P ratio of ~\ 1.7). Cellular in vitro studies with human osteosarcoma cell line (Saos-2) and human adipose-derived stem cells (hASCs) showed that PLLA-BBGs are not cytotoxic to cells, while demonstrating their capacity to promote cell adhesion and proliferation. Overall, we showed that the proposed scaffolds present a tailored kinetics on the release of inorganic species and controlled biological response under conditions that mimic the bone physiological environment.

}, keywords = {bioactivity, Borosilicate bioactive glasses, Interconnected porosity, Poly-L-lactic acid, Scaffold}, issn = {0928-4931}, doi = {10.1016/j.msec.2016.10.007}, url = {http://www.sciencedirect.com/science/article/pii/S0928493116316526}, author = {Fernandes, J. S. and Reis, R. L. and Pires, R. A.} }

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