Gellan-Gum Coated Gold Nanorods as Intracellular Drug Release System for Regenerative Medicine

last updated: 2015-05-11
ProjectRL2 – SCN :: publications list
TitleGellan-Gum Coated Gold Nanorods as Intracellular Drug Release System for Regenerative Medicine
Publication TypeComunications - Poster
Year of Publication2015
AuthorsVial S., Vieira S., Carvalho M., Reis R. L., Granja P. L., and Oliveira J. M.
Abstract

Due to their unique physicochemical properties, gold nanorods (AuNR) have been widely studied for biomedical applications including diagnosis, cell tracking, thermal therapy and drug delivery system (DDS). Their optical properties, their easy of synthesis, their ability to be functionalized with a wide variety of biomolecules and small molecules and their high surface area make them interesting as drug delivery carrier for regenerative medicine. However, to improve their biocompatibility and stability under biological conditions, surface modification needs to be envisaged, while enable the controlled release of drugs/bioactive agents. In this purpose, the coating of gold nanorods within hydrogel as Gellan Gum (GG), a biodegradable and biocompatible natural-based polymers, will allow to increase dramatically the drug payload and fulfill the requirement needed to develop an efficient DDS.

Conference NameSociety For Biomaterials 2015 Annual Meeting and Exposition: Driving Biomaterial Innovation and the Race to Translation
Date Published2015-04-16
Conference LocationCharlotte, USA
Keywordsgold nanorods, Surface modification
RightsopenAccess
Peer reviewedno
Statuspublished

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