Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Nanoparticulate bioactive-glass-reinforced gellan-gum hydrogels for bone-tissue engineering

Abstract

his work presents bioactive-glass-reinforced gellan-gum spongy-like hydrogels (GG-BAG) as novel hydrophilic materials for use as the scaffolding in bone-tissue engineering. The reinforcement with bioactive-glass particles resulted in an improvement to the microstructure and to the mechanical properties of the material. These mechanical properties were found to be dependent on the composition and improved with the amount of bioactive glass; however, values necessary to accommodate biomechanical loading were not achieved in this study. Nevertheless, by incorporating the bioactive-glass particles, the composite material acquired the ability to form an apatite layer when soaked in simulated body fluid. Furthermore, human-adipose-derived stem cells were able to adhere and spread within the gellan-gum, spongy-like hydrogels reinforced with the bioactive glass, and remain viable, which is an important result when considering their use in bone-tissue engineering. Thus, hydrogels based on gellan gum and bioactive glass are promising biomaterials for use either alone or with cells, and with the potential for use in osteogenic differentiation.

Journal
Materials Science and Engineering C
Volume
43
Pagination
27-36
Publisher
Elsevier B V
ISSN
0928-4931
Keywords
bioactive glass, Gellan Gum
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
ISWA
Year of Publication
2014
DOI
10.1016/j.msec.2014.06.045
Date Published
2014-10-01
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