Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

In Vivo Biodistribution of Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles in Rats

Abstract

Carboxymethylchitosan/poly(amidoamine) (CMCht/PAMAM) dendrimer nanoparticles, comprised of a PAMAM dendrimer core grafted with chains of CMCht, have recently been proposed for intracellular drug delivery. In previous reports, these nanoparticles had lower levels of cytotoxicity when compared with traditional dendrimers. In this study, the short-term in vivo biodistribution of fluorescein isothiocyanate (FITC)-labeled CMCht/PAMAM dendrimer nanoparticles after intravenous (IV) injections in Wistar Han rats was determined. The brain, liver, kidney, and lung were collected at 24, 48, and 72 h after injection and stained with phalloidin–tetramethylrhodamine isothiocyanate (TRITC, red) and 4

Journal
Journal of Bioactive and Compatible Polymers
Volume
26
Issue
6
Pagination
619–627
Keywords
biodistribution, carboxymethylchitosan, Central nervous system, dendrimer nanoparticles, Drug delivery systems, Fluorescence, In vivo, intracellular nanoparticles, poly(amidoamine) dendrimers
Rights
Open Access
Peer Reviewed
Yes
Status
published
Year of Publication
2011
Date Published
2011-12-06
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