In Vivo Biodistribution of Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles in Rats

last updated: 2014-12-10
TitleIn Vivo Biodistribution of Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles in Rats
Publication TypePapers in Scientific Journals
Year of Publication2011
AuthorsPereira V. H., Salgado A. J., Dr. Oliveira J. M., Cerqueira S. R., Frias A. M., Fraga J. S., Roque S., Falcão A. M., Marques F. M., Neves N. M., Mano J. F., Reis R. L., and Sousa N.
Abstract

Carboxymethylchitosan/poly(amidoamine) (CMCht/PAMAM) dendrimer nanoparticles, comprised of a PAMAM dendrimer core grafted with chains of CMCht, have recently been proposed for intracellular drug delivery. In previous reports, these nanoparticles had lower levels of cytotoxicity when compared with traditional dendrimers. In this study, the short-term in vivo biodistribution of fluorescein isothiocyanate (FITC)-labeled CMCht/PAMAM dendrimer nanoparticles after intravenous (IV) injections in Wistar Han rats was determined. The brain, liver, kidney, and lung were collected at 24, 48, and 72 h after injection and stained with phalloidin–tetramethylrhodamine isothiocyanate (TRITC, red) and 4

JournalJournal of Bioactive and Compatible Polymers
Volume26
Issue6
Pagination619–627
Date Published2011-12-06
Keywordsbiodistribution, carboxymethylchitosan, Central nervous system, dendrimer nanoparticles, Drug delivery systems, Fluorescence, In vivo, intracellular nanoparticles, poly(amidoamine) dendrimers
RightsopenAccess
Peer reviewedno
Statuspublished

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