Research Projects
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Coordination of European Commission (EC) Funded projects
EXPERTISSUES
Title Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage Using Second Generation Biomimetic Scaffolds Type: Network of Excelence (NoE) Contract Number: NMP3-CT-2004-500283-2 Funding Agency EU-EC Funding Program FP6 Budget Total = €7300000,00 M 3B's = €1796861,66 M Coordination Institution: 3B’s Research Group – University of Minho (Portugal) Principal Coordinator: Rui L. Reis Number of Partners: 20 Duration Start Date:2004-10-01 End Date:2009-09-30 Description Click here to show/hide the description The main aim of the proposed network of excellence (NoE) is to combat and overcome fragmentation of European Research on the field of Tissue Engineering of Bone and Cartilage. The network will bring together Europe’s leading academic centres and several complementary industrial players in a multi-disciplinary consortium to conduct and structure research that is able to compete in the international arena, namely with USA and Japan. The constitution of this network of excellence will lead to a complete restructuring and reshaping of the European research in this field. The optimised size of the network (20 partners from 13 countries, including 9 of the EU member states), and the selection of its original members, was designed in order to join together the critical mass and all the expertises needed to be an unavoidable world reference on the topic of tissue engineering of bone and cartilage. In order to achieve its quite demanding goals, the network also incorporates academic (but not industrial) partners of leading institutions in the USA, Canada and Singapore. These partners, leaded in most cases by researchers of EU nationality, agreed to join the network efforts by bringing in a specific expertise that will help to move European research on that particular topic. The aim of the present proposal is to establish Europe as the international scientific leader within the area of tissue engineering of bone and cartilage. The scientific aim of the network is the development of advanced functional materials that are needed for improved quality of life of thousands of patients suffering from cartilage or bone tissue loss or malfunctioning. The improved therapy suggested herein will result in a decreased morbidity and mortality of patients with reduction of the overall costs in European healthcare systems. This is particularly relevant if we take into account the increasing ageing of the population in Europe together with the increasing life expectancy, which led to a tremendous growth of age-related problems. Women are particularly affected by osteoporosis, a devastating disease for the quality of life, and they could benefit very much from the development of new therapies for bone tissue engineering.
The scientific and management committee of the network is its core, and integrates a group of partners with great reputation and expertise in distinct fields, from development of raw-materials for the production of bio-hybrid systems for tissue engineering applications, to the in-vivo functionality evaluation of the developed biomaterials. It combines groups coming from academic and research institutions and also from industry. Great emphasis is devoted to the participation of industrial partners in this NoE since, apart from their industrial experience (know-how, product development and technology transfer/protection) the network aims at develop knowledge that can sustain the development of intellectual property and products that can be used, and constitute breakthroughs, clinically. Furthermore, the NoE has partners that have been in many cases working together before and have a great experience on international collaborations. Several of the academic and industrial partners, have been involved on some of the most successful and more highly funded EU biomaterials projects in FP4 and FP5 (see EU press-release on http://europe.eu.int/comm/research/growth/gcc/projects/in-action-biomat01.html) namely those that were more connected to bone and cartilage. Having into account the expertise of the different partners, it can be affirmed that the participants who will integrate this NoE are already conducting relevant and excellent research in the area of the development of integrated biomaterials for tissue engineering applications. Furthermore, the background of each partner, and the facilities present at the integrating organisations (expertise, human resources, equipment, laboratories) will be exploited to carry out a joint programme of activities based on technical and scientific innovation. These joint activities will promote real breakthroughs in the EU research activities, leading to innovation in many areas and consequently will contribute for the reinforcement of European organizations, at the scientific and technical level, and improvements on the quality of life of citizens in general. The companies of the partnership are not expected to develop alone one complete product able to be competitive in the international market. Being part of this network, they will work together, with other companies, not belonging to the Network, and their academic partners, to make use of the knowledge and intellectual property generated by the NoE in order to develop products, technologies and therapeutic procedures in the near future.URL: http://www.expertissues.eu LA ICVS/3Bs - 2015-2017
Title Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Type: FCT R&D Project Contract Number: LA ICVS/3Bs-2015-2020 Reference: LA ICVS/3Bs-2015-2020 Funding Agency FCT Funding Program FEDER/COMPETE Budget Total = €4680000 M 3B's = €2340000 M Coordination Institution: UM-3Bs Principal Investigator: Rui Reis 3B's Coordinator: Rui Reis Number of Partners: 1 Duration Start Date:2015-01-01 End Date:2018-12-31 publications list FoReCaST
Title Forefront Research in 3D Disease Cancer Models as in vitro Screening Technologies Type: Horizon 2020 Contract Number: 668983-FoReCaST Reference: n.a. Funding Agency EU-EC Funding Program Horizon 2020 Budget Total = €2499755 M 3B's = €2499755 M Coordination Institution: UMinho Principal Investigator: Rui L. Reis 3B's Coordinator: Rui L. Reis Number of Partners: 7 Duration Start Date:2015-06-01 End Date:2020-06-01 URL: http://forecast.3bs.pt/ publications list ComplexiTE
Title An integrated multidisciplinary tissue engineering approach combining novel high-throughput screening and advanced methodologies to create complex biomaterials-stem cells constructs Type: ERC Contract Number: 321266 Reference: n/a Funding Agency EU-EC Funding Program ERC Budget Total = €2320000 M 3B's = €2320000 M Coordination Institution: UMinho Principal Investigator: Prof. Rui Reis 3B's Coordinator: Prof. Rui Reis Number of Partners: 1 Duration Start Date:2013-05-01 End Date:2018-04-30 Description Click here to show/hide the description New developments on tissue engineering strategies should realize the complexity of tissue remodeling and the inter-dependency of many variables associated to stem cells and biomaterials interactions. ComplexiTE proposes an integrated approach to address such multiple factors in which different innovative methodologies are implemented, aiming at developing tissue-like substitutes with enhanced in vivo functionality. Several ground-breaking advances are expected to be achieved, including: (i) improved methodologies for isolation and expansion of sub-populations of stem cells derived from not so explored sources such as adipose tissue and amniotic fluid; (ii) new macromolecules isolated from renewable resources, especially from marine origin; (iii) combinations of liquid volumes mingling biomaterials and distinct stem cells, generating hydrogel beads upon adequate cross-linking reactions; (iv) optimised culture of the produced beads in adequate 3D bioreactors and a novel selection method to sort the beads that show a (pre-defined) positive biological reading; (v) random 3D arrays validated by identifying the natural polymers and cells composing the positive beads; (vi) 2D arrays of selected hydrogel spots for brand new in vivo tests, in which each spot of the implanted chip may be evaluated within the living animal using adequate imaging methods; (vii) new porous scaffolds of the best combinations formed using distinct technologies, namely particles agglomeration or fiber-based rapid-prototyping. The ultimate goal of this proposal is to develop breakthrough research specifically focused on the above mentioned key issues and radically innovative approaches to produce and scale-up new tissue engineering strategies that are both industrially and clinically relevant, by mastering the inherent complexity associated to the correct selection among a great number of combinations of possible biomaterials, stem cells and culturing conditions.URL: http://complexite.3bs.pt publications list BioHybrid
Title Biohybrid templates for peripheral nerve regeneration Type: Collaborative Project - SME-targeted Contract Number: 278612 Reference: n/a Funding Agency EU-EC Funding Program FP7 Budget Total = €7755600,00 M 3B's = €266600,00 M Coordination Institution: Medizinische Hochschule Hannover, Hannover, Germany Principal Investigator: Prof. Claudia Grothe 3B's Coordinator: Rui L. Reis Number of Partners: 0 Duration Start Date:2011-10-01 End Date:2015-10-01 Description Click here to show/hide the description The main objective of the BIOHYBRID project is the development of a regenerative therapy using an innovative biohybrid artificial nerve device with the goal of repairing damaged nerve trunks. The work program includes an integrated experimental approach bringing together the main aspects of regenerative medicine: a) reconstructive microsurgery, b) regenerative scaffolds and c) transplantation. This approach will allow the biological pre-fabrication of biohybrid nerve devices, their transplantation into nerve gaps in various animal models and the comprehensive evaluation of the regenerative outcome. The SME involvement, for the first time in this biomedical field, will not be limited to production and supply of materials and services but includes also active participation in the conduction of the experiments for in vivo preclinical assessment and follow-up. Based on the extensive basic and clinical experience within this consortium a biohybrid artificial nerve device will be developed together with standardised application and evaluation parameters. A key objective of this study will be to generate, for the first time, a protocol that can serve as a template for future clinical trials in the regenerative therapy of damaged peripheral nerves. The BIOHYBRID project with its consortium partners combines excellent expertise to successfully reach the objectives and stands therfore on the front line of regenerative medicine approaches. We are looking for the production of a bio-inspired and bio-active nerve graft device, e.g. an artificial organ which not only passively substitutes the damaged nerve tissue but also activates the biological processes inside the receiving tissue (bio-activation). As shown in the figure above, we aim to promote the regeneration process through various strategies: (1) Creating a construct – with optimal porosity and layers degrading at a programmed rate – which activates the biological repair process by its 3D-structure formed by a hydrogel or nanofibres; manipulating the main properties of the construct (e.g., length, diameter, rigidity, permeability, degradability, interior surface morphology, luminal constitution, etc.) in order to meet the clinical requirements; in particular, the components which are most suitable to promote nerve regeneration are cells (especially glial cells) and bio-active molecules (such as neurotrophic factors) that are main players in the degeneration/regeneration scenario after nerve injury; the artificial nerve guide device can thus be enhanced with the enrichment of supportive cells and exogenous neurotrophic factors into the lumen. A neurotrophic factor delivery system and/or preformed instructive neurotrophic factor gradients should be part of the biohybrid artificial nerve in order to provide temporally optimised neurotrophic factor supply. Transplantation of supportive cells further creates the potential to induce the synthesis of various factors which are important for the activation of biological regeneration processes through gene transfer.URL: http://kongress.mh-hannover.de/biohybrid/6349.html publications list Printendon
Title “Development of a tendon/ligament substitute through bioprinting” Type: Marie Curie Actions (MCA) - People Contract Number: 706996 Reference: 706996 Funding Agency EU-EC Funding Program Horizon 2020 Budget Total = €160635 M 3B's = €160635 M Coordination Institution: University of Minho Principal Investigator: Manuela Gomes 3B's Coordinator: Manuela Gomes Number of Partners: 1 Duration Start Date:2016-09-01 End Date:2020-09-01 ECM_INK
Title Cells-self Extracellular Matrices-based Bioinks to create accurate 3D diseased skin tissue models Type: ERC Contract Number: 726061 Reference: - Funding Agency EU-EC Funding Program ERC Budget Total = €1998939 M 3B's = €1998939 M Coordination Institution: University of Minho Principal Investigator: Alexandra Marques 3B's Coordinator: Alexandra Marques Number of Partners: 1 Duration Start Date:2017-05-01 End Date:2022-04-30 Description Click here to show/hide the description To explore the potential of skin cells-self ECM, from healthy donors and diseased patients, produced under the principles of cell sheet engineering as an added value of new bioinks. \r\nTo propose an alternative polymer to be used in new bioinks, that will provide mechanical support to the cells-self ECM after crosslinking, allowing the formation of stable 3D bioprinted structures. \r\nTo explore submerged biofabrication conditions to overcome potential mechanical instability of the generated 3D structures while being printed.\r\nTo explore innovative bioprinting conditions to create a hollow 3D branched tree in the dermis-like analogues, and an in-house developed and patented bioreactor to perfuse media and/or cell suspensions through the structure. \r\nTo promote the vascularization of the bioprinted 3D structures by endothelialisation of the branched tree and subsequent optimization of the dynamic culture conditions to promote the sprouting of the cells into the dermis-like part of the models;\r\nTo generate a functional immune-like system currently absent in 3D skin tissue analogues and whose mechanisms are only possible to address in animal models that present important differences to humans. \r\nTo integrate the generated methods into a disruptive technology to biofabricate accurate and pathophysiological relevant 3D in vitro diseased skin tissue models. \r\nDES.SOLVE
Title When solids become liquids: Natural Deep Eutectic Solvents for chemical process engineering Type: ERC Contract Number: 725034 Reference: SEP-210336577 Funding Agency EU-EC Funding Program ERC Budget Total = €1877006,00 M 3B's = €1877006,00 M Coordination Institution: Universidade do Minho Principal Investigator: Universidade do Minho 3B's Coordinator: Ana Rita Duarte Number of Partners: 1 Duration Start Date:2017-03-01 End Date:2022-02-28 publications list Gene2Skin
Title Roadmap for advanced genetic engineering-based skin therapies Type: Horizon 2020 Contract Number: 692221 Reference: - Funding Agency EU-EC Funding Program Horizon 2020 Budget Total = €993018,75 M 3B's = €530603,75 M Coordination Institution: University of Minho Principal Investigator: Rui Reis 3B's Coordinator: Alexandra Marques Number of Partners: 3 Duration Start Date:2015-12-01 End Date:2018-11-30 Description Click here to show/hide the description With the establishment of a strong link with the proposed excellence partners the ultimate goal of this action is to define a strategic plan to develop and propose, respectively under and behind the scope of GENE2SKIN, better and safer advanced therapies for skin disorders/diseases. \\\\\\\\r\\\\\\\\nTo achieve the main objectives, specific goals were established:\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n - Increase the impact and visibility of the performed research that will contribute to demonstrate enhanced excellence and to guarantee a successful participation in competitive national and EU research programmes; \\\\\\\\r\\\\\\\\n- Attract private/ Maecenas investment;\\\\\\\\r\\\\\\\\n- Promote innovation and the generation of intellectual property as a mean to potentiate the created knowledge and its translation into products/services;\\\\\\\\r\\\\\\\\n- Foster the networking with the European, national and regional Portuguese authorities to guarantee positioning in relevant regulatory frameworks and stimulate R&D compliant with appropriate regulatory framework;\\\\\\\\r\\\\\\\\n- Reduce the gap between academia and industry by impacting the qualification and employment rate of the local population as well as fostering the creation of new business opportunities;\\\\\\\\r\\\\\\\\n- Offer appealing conditions (strategic and of excellence collaboration network; state-of-the-art research facilities; entrepreneur culture; developed translational mindset) to develop scientific and technological research of excellence capable of attracting talented researchers.URL: http://gene2skin.eu publications list CHEM2NATURE
Title Enabling precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices Type: Horizon 2020 Contract Number: n.a. Reference: n.a. Funding Agency EU-EC Funding Program Horizon 2020 Budget Total = €1000000 M 3B's = €700000 M Coordination Institution: University of Minho Principal Investigator: João F. Mano 3B's Coordinator: João F. Mano Number of Partners: 4 Duration Start Date:2016-01-01 End Date:2019-01-01 publications list -
Participation in European Commission (EC) Funded projects
NanoTech4ALS
Title MRI-guided, intrathecal delivery of nanogel-embedded glial progenitors for treatment of amyotrophic lateral sclerosis Type: FP7 Programme Contract Number: EuronanomedII-2015 Reference: N/A Funding Agency EU-EC Funding Program ERA-Net Budget Total = €891972 M 3B's = €124896 M Coordination Institution: University of Warmia and Mazury in Olsztyn Principal Investigator: Piotr Walczak 3B's Coordinator: Joana Silva-Correia Number of Partners: 4 Duration Start Date:2016-09-01 End Date:2019-11-30 Description Click here to show/hide the description This proposal is directly responsive and fits the scope of this call because: it is centred at Regenerative Medicine as glial progenitor cells will be used to treat amyotrophic lateral sclerosis. Proposed studies include Targeted Delivery Systems such as MRI-guided injection of cells into the intrathecal space or utilization of functionalized nanoparticles for delivery of therapeutic payload specifically targeted towards transplanted glial progenitors and/or endogenous neurons. We will capitalize on recent discoveries in the filed of stem cells, specifically the breakthrough discovery about the role of glia on the function of motor neurons, and, on the latest achievements of nanotechnology such as utilization of nanoparticles for targeting therapeutic payloads specifically towards target cells with controlled long-lasting release. This convergence of nanotechnology and stem cell technology is particularly promising for the success of novel regenerative medicine approaches.publications list SponGES
Title Deep-sea Sponge Grounds Ecosystems of the North Atlantic Type: Horizon 2020 Contract Number: 679849 Reference: SEP 679849-2 Funding Agency EU-EC Funding Program Horizon 2020 Budget Total = €9994302,75 M 3B's = €374680,00 M Coordination Institution: University of Bergen, Norway Principal Investigator: Hans Tore Rapp 3B's Coordinator: Rui L. Reis Number of Partners: 15 Duration Start Date:2016-03-01 End Date:2020-03-01 Description Click here to show/hide the description Deep-sea sponge-dominated communities (grounds, aggregations and gardens) form a variety of vulnerable marine ecosystems widespread throughout the North Atlantic in areas such as shelves, slopes, seamounts, mid-ocean ridges, canyons and fjords which often coincide with fishing and other human activities. Their biodiversity, ecological importance and biotechnological potential is assumed to be similar to or even higher than other deep-sea ecosystems such as cold-water coral reefs or vents/seeps systems. However, in contrast to those, sponge grounds have so far received relatively little scientific or conservation attention.\\\\\\\\r\\\\\\\\nThe overall objective of SponGES is to develop an integrated ecosystem-based concept for the preservation and sustainable exploitation of vulnerable deep-sea sponge ecosystems of the North Atlantic.\\\\\\\\r\\\\\\\\nBy establishing an international and interdisciplinary consortium of researchers from institutions, environmental non-governmental and intergovernmental organizations, SponGES will specifically aim: 1 - Strengthening the knowledge-base on North Atlantic sponge ground ecosystems by investigating their distribution, diversity, biogeography, function and dynamics (WP1-4); 2 - Improving innovation and industrial application by unlocking the biotechnological potential of these ecosystems (WP5); 3 - Improving the capacity to model, understand and predict threats and impacts and future anthropogenic and climate-driven changes to these ecosystems (WP6-7); 4 - Advancing the science-policy interface and developing tools for improved resource management and good governance of these ecosystems from regional to international levels across the North Atlantic (WP8-9).Tendon Therpy Train
Title Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair Type: Marie Curie Actions—Initial Training Networks (ITN) Contract Number: 676338 Reference: 676338 Funding Agency EU-EC Funding Program Horizon 2020 Budget Total = €40000000 M 3B's = €238356 M Coordination Institution: Univ Galway, Irland Principal Investigator: Dimitrios Zeugolis 3B's Coordinator: Rui Reis/Manuela Gomes Number of Partners: Duration Start Date:2016-02-01 End Date:2023-01-31 Description Click here to show/hide the description The Tendon Therapy Train programme will develop the world’s first three-dimensional cell assembled prototype for tendon repair, the clinical relevance of which will be assessed in suitable preclinical models to demonstrate\\\\r\\\\nproof of principle (Figure 1). The driving hypothesis is that an in vitro microenvironment that will imitate the native human / equine tendon tissue milieu will maintain the phenotype of tendon derived cells (TDCs) and\\\\r\\\\ndifferentiate bone marrow stem cells (BMSCs), adipose derived stem cells (ADSCs) and dermal fibroblasts (DFs) towards tenogenic lineage and ultimately facilitate the development of a functional cell assembled tendon equivalent. The Tendon Therapy Train network will train 15 early stage researchers (ESRs) to doctoral level and equip them with educational, research, clinical, commercial and regulatory expertise that will enable establishing European competitiveness in the field of ATMPs. The 15 ESRs will be recruited for 540 research months (RMs) in total; 129 RMs will be spent in secondments. The individual ESR projects will be harmonically orchestrated into the integrated programme (Figure 1), which is subdivided into 6 specific objectives (SO):\\\\r\\\\n¨ SO1: Engineering optimal culture conditions to maintain human / equine TDC phenotype.\\\\r\\\\n¨ SO2: Engineering optimal culture conditions to differentiate human / equine BMSCs, ADSCs and DFs\\\\r\\\\ntowards tenogenic lineage.\\\\r\\\\n¨ SO3: Development of three-dimensional human / equine cell-assembled tendon substitutes.\\\\r\\\\n¨ SO4: Assessment of the developed prototypes in suitable preclinical models.\\\\r\\\\n¨ SO5: Development of roadmap to commercialisation.\\\\r\\\\n¨ SO6: Development of world-class doctoral programme in ATMPs.publications list BEAM
Title Biomedical Engineering - EU Australian cooperation at master level Type: N/D Contract Number: 388414-EM-1-2014-1-IT-ERA MUNDUS-ICIJMP Reference: 388414-EM-1-2014-1-IT-ERA MUNDUS-ICIJMP Funding Agency EU-EC Funding Program - Budget Total = €197500,00 M 3B's = €66500,00 M Coordination Institution: University of Trento Principal Investigator: University of Trento 3B's Coordinator: Project Partner Number of Partners: 5 Duration Start Date:2014-10-01 End Date:2018-09-30 Description Click here to show/hide the description BEAM is a Joint Mobility Project involving the Universities of Trento (UNITN), Martin Luther University Halle-Wittenberg (MLU) and Minho University (UMH) in Europe and the Australian: Queensland University of Technology (QUT, Brisbane, Queensland), and University of Sydney (US) New South Wales to develop and test joint teachings at master level, shared and complementary modules to promote focused students and lecturers mobility. \\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nThe project will foster EU-Australia cooperation by defining an enhanced mobility scheme based on a sound academic programme at master level in the field of biomedical engineering, tissue engineering and regenerative medicine. \\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nBEAM aims at educating skilled professionals who can operate in the design, fabrication, and testing of new biomedical materials using cutting-edge technologies in research and technological environments, and to develop a shared, rigorous and coherent graduate program in biomedical and tissue engineering offering expanded academic and learning opportunities, and make effective use of innovative teaching and learning strategies and methodologies:\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n-To promote original, high quality research by emphasising the intellectual importance of transnational, interdisciplinary approaches and methodologies to the study of Biomedical sciences. \\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n-To promote greater knowledge and understanding of latest developments of biomedical sciences and start ongoing cooperation with colleagues, scientists and professionals in academia, companies and governments.\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nThe enhanced educational experience will involve students and staff in both a virtual and actual community.\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n-To develop long term, sustainable research collaboration between the faculty staff of participating institutions. \\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n-To strengthen transnational cooperative academic and administrative networks between Australia and the EU starting by participating institutions and suitable to include different stakeholders in EU-AU and establish the foundations of life sciences supporting technologies hubs, ensuring the long-term viability of the BEAM program beyond its lifespan.\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n-To provide opportunities for graduate students to deepen their intercultural understanding of AU-EU societies through language training and cultural activities.\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n-To establish Quality Assurance processes and procedures to assess and monitor the project’s progresses and overall effectiveness in the achievement of BEAM ultimate goals.\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nThroughout the course analysis and program development, punctual mobility arrangements will maximise academic advantage for students, in terms of diversity and strength of contents. \\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nTransparency and mutual recognition of qualifications, study, research and training periods abroad, will be supported by individual agreements facilitating the reciprocal credits recognition and transfer. BEAM Masters student will gain personal development, improved academic opportunities, qualifications and professional experience and a deeper knowledge and understanding of biomedical and tissue engineering, and its therapeutic outcomes. Tissue engineering and regenerative medicine applications are key topics in EU framework and excellence research programmes. \\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nBEAM programme aims at educating a novel generation of bio-engineers by providing complementary training such as basic biomaterials science, biology, clinical requirements, including technology transfer and intellectual properties opportunities. Worth noting is the fact the UMinho and UTrento are partners in the European Institute for Tissue Engineering and Regenerative Medicine.\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nAs well-known, excellence in teaching is driven by excellence in research: the BEAM programme gathers a team of research leaders in the field of biomedical science and tissue engineering in order to translate the latest research findings into teaching material for achieving educational excellence.\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nIn a globalised context, with fast increasing international expectations, a training delivered by a national university cannot address the challenges of the field. The BEAM international perspective harmonises visions that are similar in science, being however oriented to systems operating in totally different geographic and economic contexts. \\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nBEAM educational team is composed of a mixture of mid-career, senior researchers and lecturers, ensuring latest advancements and high-level teachings. Complementary training in biomaterials basics science, biology, clinical requirements and cutting edge techniques and methodologies will pave the way to a new bio-engineers generation able to cope with future challenges in a rapidly evolving field and whose skills will increase employability and attractiveness for research and industry employers.ELASTISLET
Title Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche Type: Horizon 2020 Contract Number: H2020-NMP-2014-646075 Reference: H2020-NMP-2014-two-stage ref. 646075 Funding Agency EU-EC Funding Program Horizon 2020 Budget Total = €6214496,00 M 3B's = €301121,88 M Coordination Institution: University of Valladolid Principal Investigator: José Carlos Rodríguez-Cabello 3B's Coordinator: João F. Mano Number of Partners: 11 Duration Start Date:2015-06-01 End Date:2019-05-31 Description Click here to show/hide the description Milestones assigned to 3B: M8 - Optimized protocol for cell LbL coating - Month 9; M16 - First coated hiPSC single cells (strat. B) - Month 15publications list BAMOS
Title Biomaterials and Additive Manufacturing: Osteochondral Scaffold innovation applied to osteoarthritis Type: Marie Curie Actions (MCA) - People Contract Number: 20912 Reference: H2020-MSCA-RISE-2016-734156 Funding Agency EU-EC Funding Program Horizon 2020 Budget Total = €639000,00 M 3B's = €166500 M Coordination Institution: Universidad de Las Palmas de Gran Canaria (ULPGC) Principal Investigator: Mario Verona 3B's Coordinator: Rui Reis Number of Partners: 7 Duration Start Date:2017-01-16 End Date:2021-01-15 URL: http://www.risebamos.eu/index.php Flexpol
Title Antimicrobial Flexible Polymers for its use in Hospital Environments Type: Horizon 2020 Contract Number: H2020-NMBP-PILOTS-2016 721062 Reference: H2020-NMBP-PILOTS-2016 721062 Funding Agency EU-EC Funding Program - Budget Total = €5677717.5 M 3B's = €807737.5 M Coordination Institution: Fraunhofer IPT Principal Investigator: Fraunhofer IPT 3B's Coordinator: Prof. Nuno Neves Number of Partners: 7 Duration Start Date:2017-01-02 End Date:2023-01-01 URL: http://flexpol.eu -
Industrial Funded Projects
Mysfyt
Title New molecules for advanced cosmetics Type: Industrial Project Contract Number: n/a Reference: n/a Funding Agency Industrial Funding Program Industrial Budget Total = €37700 M 3B's = €37000 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2017-02-01 End Date:2019-03-31 Description Click here to show/hide the description Synthesis of molecules with cosmetic relevance and formulation of consumer products.WineComp
Title Soluções técnicas em materiais biocompósitos cortiça-polímero para aplicação em vinhos. Type: Industrial Project Contract Number: None Reference: WineComp Funding Agency Industrial Funding Program Industrial Budget Total = €220000 M 3B's = €220000 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2016-05-01 End Date:2019-04-30 publications list -
FCT (Portuguese Foundation for Science and Technology) Funded Projects
CytoNanoHeal
Title Engineered nanotools for advanced cell therapies Type: ERA-Net Contract Number: ENMed/0001/2015 Reference: ENMed/0001/2015 Funding Agency FCT Funding Program - Budget Total = €79621,00 M 3B's = €79621,00 M Coordination Institution: Universitat Politècnica de Catalunya Principal Investigator: Tzanko Tzanov 3B's Coordinator: Iva Pashkuleva Number of Partners: 5 Duration Start Date:2016-01-01 End Date:2022-01-01 publications list Dez.Zyme
Title Separação biocataltica de enantiomeros usando Solventes Eutecticos Naturais Type: FCT R&D Project Contract Number: PTDC/BBB-EBB/1676/2014 Reference: PTDC/BBBEBB/ 1676/2014 Funding Agency FCT Funding Program - Budget Total = €168535 M 3B's = €60838 M Coordination Institution: Universidade Nova de Lisboa Principal Investigator: Alexandre Paiva 3B's Coordinator: Joana Marques Silva Number of Partners: 2 Duration Start Date:2016-04-04 End Date:2019-04-04 Description Click here to show/hide the description It is the aim of DESZYME to develop the applications of Natural Deep Eutect Solvents (NADES) in biocatalysis. NADES are a new class of solvents derived from Deep Eutectic Solvents (DES) which are composed by natural metabolites such as sugars, carboxylic acids, amino acids and choline based organic salts. An eutectic solvent is a mixture of two solid components that at\r\nspecific composition suffer a deep melting point depression. DES is composed by a hydrogen bond donor and a hydrogen bond acceptor. They share many similarities with ionic liquids (IL), but overcome the major drawbacks of IL, namely, the high production cost and their controversial “greenness”. NADES raw materials are cheap, abundant and available in Nature, making\r\nthem cheap and green alternatives to IL. They are considered to be the solvent of the XXIst century. The opportunities for this solvents are enormous and their application in biocatalysis has just started to be address by the scientific community. About one third of the just 34 papers in the subject were published in the last year. There is a considered lack of knowledge in this\r\nsubject which DESZYME intends to overcome. The characteristics of NADES envisages three main applications in biocatalysis: as reaction solvents, as separation agents and as substrate themselves. These will be the main applications pursued by DESZYME.publications list VESCells
Title Single-step fabrication of biofunctional blood vessel substitutes by using electrospinning technologies and mesenchymal stem cells. Type: FCT R&D Project Contract Number: PTDC/BBB-BMD/5468/2014 Reference: PTDC/BBB-BMD/5468/2014 Funding Agency FCT Funding Program POCI Budget Total = €199557,00 M 3B's = €199557,00 M Coordination Institution: 3B's Principal Investigator: Rui L Reis 3B's Coordinator: Rui L Reis Number of Partners: 1 Duration Start Date:2016-04-01 End Date:2019-10-01 publications list FOOD4CELLS
Title Engineering a biomimetic vasculature to be integrated hydrogels for regenerative medicine Type: FCT R&D Project Contract Number: POCI/01-0145-FEDER-016716 Reference: PTDC/CTMBIO/ 4706/2014 Funding Agency FCT Funding Program FEDER Budget Total = €196000,00 M 3B's = €196000,00 M Coordination Institution: Universidade do Minho (UMinho) Principal Investigator: Luísa Rodrigues 3B's Coordinator: Luísa Rodrigues Number of Partners: Duration Start Date:2016-06-01 End Date:2019-05-31 publications list 3BsCOP
Title 3D Bioencapsulated hydrogel(s) Constructs for Organ Printing: From Concept to Reality Type: FCT R&D Project Contract Number: na Reference: PTDC/BBB-ECT/3213/2014 Funding Agency FCT Funding Program - Budget Total = €199605,00 M 3B's = €199605,00 M Coordination Institution: 3Bs research group Principal Investigator: Praveen Sher 3B's Coordinator: Praveen Sher Number of Partners: 0 Duration Start Date:2016-04-01 End Date:2019-03-31 MicroLiver
Title A novel bicompartmentalized hydrogel microcapsule as 3D coculture system for liver tissue microengineering and drug-induced hepatotoxicity screening Type: FCT R&D Project Contract Number: POCI-01-0145-FEDER-016715 Reference: PTDC/BBB-ECT/4317/2014 Funding Agency FCT Funding Program - Budget Total = €196005 M 3B's = €196005 M Coordination Institution: Principal Investigator: Dillip Bishi 3B's Coordinator: Dillip Bishi Number of Partners: Duration Start Date:2016-06-01 End Date:2019-05-31 publications list B-FABULUS
Title BioFABrication of fUnctionaLized scaffolds for patient-specific meniscUS regeneration Type: FCT R&D Project Contract Number: PTDC/BBB-ECT/2690/2014 Reference: PTDC/BBB-ECT/2690/2014 Funding Agency FCT Funding Program PTDC Budget Total = €199257,00 M 3B's = €199257,00 M Coordination Institution: University of Minho Principal Investigator: 3B's Coordinator: Joana Silva-Correia Number of Partners: Duration Start Date:2017-02-01 End Date:2020-01-31 publications list HierarchiTech
Title Hierarchical Ionic-doped Nanocomposite Scaffolds for Osteochondral Tissue Engineering Type: N/D Contract Number: M-ERA NET Reference: M-ERA-NET Funding Agency FCT Funding Program OE-PIDDAC Budget Total = €296410,00 M 3B's = €121410,00 M Coordination Institution: UMinho - 3Bs Principal Investigator: Rui L. Reis 3B's Coordinator: Rui L. Reis Number of Partners: 3 Duration Start Date:2015-10-01 End Date:2021-09-30 publications list HAIRquivalent
Title Bioengineered hair follicles equivalents with controlled biological and architectural configuration Type: FCT R&D Project Contract Number: EE/2015/942 Reference: IF/00945/2014 Funding Agency FCT Funding Program - Budget Total = €50000 M 3B's = €50000 M Coordination Institution: ICVS/3B's Principal Investigator: 3Bs 3B's Coordinator: Alexandra P. Marques Number of Partners: 1 Duration Start Date:2015-03-02 End Date:2020-03-01 Description Click here to show/hide the description To deconstruct dermal papilla and intradermal adipose tissue extracellular matrix;\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nTo achieve bio-instructive matrices with well controlled properties; \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nTo select matrices that potentially present the properties capable of supporting DP cell’s necessities and phenotype;\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nTo define a basement membrane-like substratum;\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nTo recreate a epithelial-mesenchymal hair follicle model;\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\nTo develop hair forming units fro tissue engineer applications.publications list RECOGNIZE
Title Intellegent scaffolds by molecular recognition for advanced applications in regenerative medicine Type: FCT R&D Project Contract Number: UTAP-ICDT/CTM-BIO/0023/2014 Reference: UTAP-ICDT/CTM-BIO/0023/2014 Funding Agency FCT Funding Program - Budget Total = €200000 M 3B's = €130000 M Coordination Institution: 3Bs Principal Coordinator: Number of Partners: 3 Duration Start Date:2015-06-01 End Date:2018-06-01 Description Click here to show/hide the description synthesis of novel imprinted polymer synthetic gel structures with specific recognition properties for large molecular weight proteins;\r\n\r\nsynthesis of novel imprinted polymer gel structures based on natural origin polymers with specific recognition properties for large molecular weight proteins;\r\n\r\nquantitative characterization and imaging of the equilibrium and kinetic binding behavior of the imprinted polymer scaffolds to template molecules;\r\n\r\nincorporation of a degradable crosslinker into the polymer backbone while still maintaining recognition capabilities\r\n\r\nin vitro investigation of cellular adhesion, proliferation, and growth on imprinted polymer gel scaffolds.\r\npublications list IF/00347/2015
Title Angiogenic Cell Sheets derived from the Stromal Vascular Fraction of Adipose Tissue to produce prevascularized osteogenic constructs Type: FCT R&D Project Contract Number: IF/00347/2015 Reference: IF/00347/2015 Funding Agency FCT Funding Program OE-PIDDAC Budget Total = €49992 M 3B's = €49992 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2017-09-01 End Date:2021-08-31 IF/01285/2015
Title Advancing Precision Medicine through the Development of In Vitro Tissue Engineered 3D Tumor Models and Multi-omics Type: FCT R&D Project Contract Number: IF/01285/2015 Reference: IF/01285/2015 Funding Agency FCT Funding Program OE-PIDDAC Budget Total = €45000 M 3B's = €45000 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2017-09-01 End Date:2020-08-31 publications list INCIPIT
Title INtegrated Conductive and biomimetic polymeric Interfaces able to serve as micro-nanostructured Patches for myocardIal regeneraTion Type: ERA-Net Contract Number: M-ERA-NET2/0001/2016 Reference: M-ERA-NET2/0001/2016 Funding Agency FCT Funding Program ERA-Net Budget Total = €136896 M 3B's = €136896 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2017-09-01 End Date:2020-08-31 TERM - Programa de Doutoramento FCT
Title Programa Doutoral em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais Type: FCT R&D Project Contract Number: PD/59/2013 Reference: PD/59/2013 Funding Agency FCT Funding Program - Budget Total = €100000 M 3B's = €100000 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2015-09-01 End Date:2019-09-01 publications list PATH
Title FCT Doctoral Program on Advanced Therapies for Health Type: FCT R&D Project Contract Number: PD/00169/2013 Reference: PD/00169/2013 Funding Agency FCT Funding Program N/D Budget Total = €100000 M 3B's = €100000 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2015-09-01 End Date:2023-09-01 URL: http://path.3bs.uminho.pt/ publications list SPARTAN
Title Preclinical Validation of a TNF-Capturing Device as Therapeutics of Inflammatory Arthritic Diseases Type: FCT R&D Project Contract Number: PTDC/CTM-BIO/4388/2014 Reference: PTDC/CTM-BIO/4388/2014 Funding Agency FCT Funding Program FEDER Budget Total = €197683 M 3B's = €197683 M Coordination Institution: Universidade do Minho Principal Investigator: Nuno Neves 3B's Coordinator: Nuno Neves Number of Partners: 1 Duration Start Date:2016-05-02 End Date:2019-05-02 publications list 3BioMeD
Title 3D bioprintable and cell-compatible Bioinks for treatment of Metabolic Diseases Type: FCT R&D Project Contract Number: FCT/4773/4/5/2017/S Reference: 3DBioMed Funding Agency FCT Funding Program FEDER Budget Total = €99810,00 M 3B's = €99810,00 M Coordination Institution: 3Bs Principal Investigator: Rui Reis 3B's Coordinator: Miguel Oliveira Number of Partners: 2 Duration Start Date:2017-05-01 End Date:2020-04-30 IF/00376/2014
Title Biofunctionalization of Biodegradable Nanofibrous Substrates Envisioning Personalized Regenerative Medicine Strategies. Type: N/D Contract Number: IF/00376/2014/CP1212/CT0015 Reference: IF/00376/2014 Funding Agency FCT Funding Program N/D Budget Total = €49200,00 M 3B's = €49200,00 M Coordination Institution: LA ICVS/3B Principal Investigator: Albino Martins 3B's Coordinator: Albino Martins Number of Partners: Duration Start Date:2016-03-01 End Date:2021-03-01 IF/00373/2014
Title SWEET&NANO-ARCHITECTURES Type: FCT R&D Project Contract Number: IF/00373/2014 Reference: IF/00373/2014 Funding Agency FCT Funding Program - Budget Total = €50000 M 3B's = €50000 M Coordination Institution: University of Minho Principal Investigator: 3bs research group 3B's Coordinator: Ramon Novoa Carballal Number of Partners: 1 Duration Start Date:2016-01-01 End Date:2022-01-01 publications list -
Other
Harvey Research Prize 2017
Title IET Harvey Research Prize 2017 Type: N/D Contract Number: Harvey A_2017 Reference: Harvey Award 2017 Funding Agency IET Institution of Engineering and TEchnology Funding Program Health Budget Total = €350000 M 3B's = €350000 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2018-04-02 End Date:2024-04-01 Description Click here to show/hide the description The main goal of this project is to develop different 3D in vitro tissue modelsor musculoskeletal and neurodegenerative diseases.BiogenInk
Title Biogenic Inks combining marine collagen and ionic-doped calcium phosphates for bone tissue engineering Type: ERA-Net Contract Number: N/A Reference: N/A Funding Agency FCT Funding Program ERA-Net Budget Total = €200412,00 M 3B's = €200412,00 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2017-09-01 End Date:2020-08-31 Dressing4scars
Title New 4D printing dressing to treat skin scars Type: ERA-Net Contract Number: -- Reference: ERA-NET / CSA / JPI/M-ERANET Funding Agency FCT Funding Program ERA-Net Budget Total = €530081 M 3B's = €199992 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2017-09-01 End Date:2020-08-31 Description Click here to show/hide the description The main objective of Dressing4scars is the design and development, following a “4D printing” approach, of a new smart responsive scaffold to be used as a skin dressing that is capable of changing “shape/mechanical cues” while new skin is being formed, counteracting pro-scarring mechanical forces. In this way, the dressing would impact the fibroblast-to-myofibroblast transition, minimizing or even avoiding then the formation of scars. \\r\\nTo achieve this goal, individual objectives will be addressed:\\r\\n• Define the mechanical requirements for the customized dressing based on a thorough biomechanical analysis of healthy, scarred and wounded skin; \\r\\n• Define a new composition and/or combination of materials to be used in the AM process;\\r\\n• Design and develop/adapt AM technologies to print the selected material(s);\\r\\n• Design and print a new smart responsive scaffold capable of supporting adequate evolution (4D);\\r\\n• Test the “4D printing” approach by assessing the mechanical evolution of the skin dressing along time and its capability to support fibroblast to myofibroblasts transition;\\r\\n• Validate the processes in an in vivo model with similar structure, function, and healing response to human cutaneous healing.\\r\\nIf successful, Dressing4scars will be able to address a new concept applied to the AM, the “4D printing” approach that is expected to revolutionize the field, Moreover, it will provide an alternative treatment for skin scars and minimize scarring during healing using customized smart responsive dressing capable to change in situ and lead anti-scarring biological responses. This represents a major breakthrough to the current state-of-the-art treatments and is expected to be foundational for the improvement of scaffolds to be used in regenerative medicine in general\\r\\nURL: http://dressing4scars.3bs.pt KrEaTive Habitat
Title Transferência e divulgação da pesquisa aplicada relacionada com as Tecnologias Facilitadoras Essenciais (KETs) para a indústria de materiais do Habitat para promover novas aplicações dentro das indústrias criativas no espaço Sudoe Type: INTERREG V SUDOE Contract Number: SOE1/P1/E0307 Reference: SOE1/P1/E0307 Funding Agency FEDER Funding Program INTERREG V SUDOE Budget Total = €1191227,77 M 3B's = €131962 M Coordination Institution: Fundación Centro Tecnológico de Componentes Principal Investigator: Antonio Segura Pérez 3B's Coordinator: Rui L. Reis Number of Partners: 7 Duration Start Date:2017-02-22 End Date:2020-02-21 URL: http://www.kreativehabitat.eu/ publications list -
Portugal2020
CVMar+i
Title Inovação industrial através de colaborações específicas entre empresas e centros de investigação no contexto de valorização biotecnológica marinha Type: POCTEP Contract Number: 0302_CVMAR_I_1_P Reference: 0302_CVMAR_I_1_P Funding Agency CCDR-N Funding Program POCTEP Budget Total = €2132000 M 3B's = €420000 M Coordination Institution: University of Minho Principal Investigator: Rui L. Reis 3B's Coordinator: Rui L. Reis Number of Partners: 19 Duration Start Date:2017-01-01 End Date:2019-12-31 URL: http://cvmari.cetmar.org/ publications list IBEROS
Title Instituto de Bioingeniería en Red para el Envejecimiento Saludable Type: POCTEP Contract Number: 0245_IBEROS_1_E Reference: 0245_IBEROS_1_E Funding Agency CCDR-N Funding Program POCTEP Budget Total = €1950000 M 3B's = €220000 M Coordination Institution: University of Vigo Principal Investigator: Pio González 3B's Coordinator: Rui L. Reis Number of Partners: 8 Duration Start Date:2016-10-01 End Date:2019-09-30 Description Click here to show/hide the description El objetivo principal del proyecto IBEROS es potenciar una investigación e innovación de excelencia en la Eurorregión que contribuya con sus resultados a mejorar la calidad de vida y salud de la población, con especial foco en las enfermedades asociadas al envejecimiento, generando al mismo tiempo nuevos nichos de mercado y empleo estable. Se crea el Instituto de Bioingeniería en Red para el Envejecimiento Saludable (IBEROS) como centro interdisciplinar de investigación, para llevar a cabo una investigación interdisciplinaria excelente en las fronteras de la ingeniería y las ciencias de la vida con el fin de generar nuevo conocimiento aunando campos como la nanomedicina, la ingeniería de tejidos, etc. en el ámbito de la salud.publications list -
Norte2020
PATH - Programa de Doutoramento Norte 2020
Title Programa Doutoramento em Terapias Avançaas para a Saúde Type: N/D Contract Number: NORTE-08-5369-FSE-000037 Reference: NORTE-08-5369-FSE-000037 Funding Agency CCDR-N Funding Program - Budget Total = €371250 M 3B's = €371250 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2016-09-01 End Date:2019-09-01 publications list TERM - Programa Doutoramento Norte 2020
Title Programa Doutoral em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais Type: N/D Contract Number: NORTE-08-5369-FSE-000044 Reference: NORTE-08-5369-FSE-000044 Funding Agency CCDR-N Funding Program - Budget Total = €371250 M 3B's = €371250 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2016-09-01 End Date:2022-08-31 publications list FROnTHERA
Title Frontiers of technology for theranostics of cancer, metabolic and neurodegenerative diseases Type: Projeto Estruturado Contract Number: NORTE-01-0145-FEDER-0000232 Reference: NORTE-01-0145-FEDER-0000232 Funding Agency CCDR-N Funding Program FEDER Budget Total = €3864360,25 M 3B's = €1590157,38 M Coordination Institution: UMinho Principal Investigator: Nuno Neves 3B's Coordinator: Nuno Neves Number of Partners: 2 Duration Start Date:2016-04-01 End Date:2019-03-31 Description Click here to show/hide the description FROnTHERA is an initiative of three top leading research units, located in the PT convergence region (Norte de Portugal, PT 11 region), and gathers experts in tissue engineering in vitro models, neurosciences and emergent technologies based on responsive biosensors, whose main goal is to advance in research for developing tools and technologies to be used as alternative to animal experimentation and in personalised therapies for human health. This new scientific endeavour will result from a research collaboration process between 3B’s (coordinator) and ICVS, both from UMINHO, and INL, institutions of research and innovation of excellence and aims to have a spillover effect on PT11 economy. The cooperation of UMINHO research units ICVS and 3B’s with INL in FROnTHERA, will help boost the scientific indicators, in terms of number of patents, number of papers (and numbers of papers per full time equivalent), their impact factors and number of citations. Importantly, they will help raise the UMINHO and INL staff’s research profile as well as the one of the institutions involved. It will also promote interactions with local biotech companies and pharma within the fields of drug development and screening (regional networking).\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nBriefly, the scientific objectives and strenthening research capacity of PT11 region will be achieved by promoting the:\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n1) scientific and technological capacity within the new domain of 3D tissue engineered models for drug screening and personalised therapies (cancer, neurodegenerative diseases, diabetes, and biosensors within the top-level Institutions 3B’s and ICVS (UMINHO), and INL.\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n2) advanced research to enhance the 3B’s and ICVS(UMINHO) and INL scientific competitiveness within the domains of tissue engineering microfluidics, and sensors;\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n3) exchange of knowledge and know how, and networking via planned secondments of experienced researchers within participant Institutions (3B’s, ICVSand INL) of excellence and active dissemination strategy (e.g. hands-on-training courses, mentoring sessions, virtual training sessions, etc);\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n4) participation of 3B’s and ICVS (UMINHO) and INL staff, and other stakeholders namely entrepreneurs, CEO’s of companies;\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\n5) networking, which can enhance the participation in international consortia that trigger the attraction of private and public EC funds (e.g. Horizon2020).\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\nURL: http://www.3bs.uminho.pt/projects#projectid-486 publications list NORTE45_3Bs
Title Accelerating tissue engineering and personalized medicine discoveries by the integration of key enabling nanotechnologies, marine-derived biomaterials and stem cells Type: Projeto Estruturado Contract Number: NORTE-01-0145-FEDER-000021 Reference: NORTE-45-2015-02: candidatura 770 Funding Agency CCDR-N Funding Program Norte2020 Budget Total = €3870000 M 3B's = €3870000 M Coordination Institution: University of MInho Principal Investigator: Rui L. Reis 3B's Coordinator: Rui L. Reis Number of Partners: Duration Start Date:2016-04-01 End Date:2019-03-31 publications list -
Internal Project
AT4MS
Title Advanced therapy to effectively treat multiple sclerosis using a biomaterial to sustain the release of mesenchymal stem cells into the central nervous system Type: N/D Contract Number: ICVS/3B Reference: AT4MS Funding Agency N/D Funding Program N/D Budget Total = €10000 M 3B's = €5000 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2016-07-29 End Date:2018-07-29 LA- Mariana Cerqueira 2016
Title Pre-Clinical potential of Cell Sheets of Adipose Stem Cells for Skin Regeneration Type: N/D Contract Number: NA Reference: NA Funding Agency N/D Funding Program N/D Budget Total = €10000 M 3B's = €10000 M Coordination Institution: Principal Coordinator: Number of Partners: Duration Start Date:2016-09-14 End Date:2018-09-14
