Advances in bioinks and in vivo imaging of biomaterials for CNS applications

last updated: 2019-09-02
ProjectNanoTech4ALS :: publications list
TitleAdvances in bioinks and in vivo imaging of biomaterials for CNS applications
Publication TypeReview Paper
Year of Publication2019
AuthorsOliveira E. P., Malysz-Cymborska I., Golubczyk D., Kalkowski L., Kwiatkowska J., Reis R. L., Oliveira J. M., and Walczak P.
EditorsDai G., and Ye K.
Abstract Text

Due to increasing life expectancy incidence ofneurological disorders is rapidly rising, thus adding urgency to develop effective strategies for treatment. Stem cell-based therapies were considered highly promising and while progress in this field is evident, outcomes of clinical trials are rather disappointing. Suboptimal engraftment, poor cell survival and uncontrolled differentiation may be the reasons behind dismal results. Clearly, new direction is needed and we postulate that with recent progress in biomaterials and bioprint- ing, regenerative approaches for neurological applications may be finally successful. The use of biomate- rials aids engraftment of stem cells, protects them from harmful microenvironment and importantly, it facilitates the incorporation of cell-supporting molecules. The biomaterials used in bioprinting (the bioinks) form a scaffold for embedding the cells/biomolecules of interest, but also could be exploited as a source ofendogenous contrast or supplemented with contrast agents for imaging. Additionally, bioprint- ing enables patient-specific customization with shape/size tailored for actual needs. In stroke or traumatic brain injury for example lesions are localized and focal, and usually progress with significant loss of tissue volume creating space that could be filled with artificial tissue using bioprinting modalities. The value of imaging for bioprinting technology is advantageous on many levels including design of custom shapes scaffolds based on anatomical 3D scans, assessment of performance and integration after scaffold implan- tation, or to learn about the degradation over time. In this review, we focus on bioprinting technology describing different printing techniques and properties of biomaterials in the context of requirements for neurological applications. We also discuss the need for in vivo imaging of implanted materials and tis- sue constructs reviewing applicable imaging modalities and type of information they can provide.

JournalActa Biomaterialia
Date Published2019-05-08
PublisherElsevier Ltd
KeywordsBioink, Bioprinting, Brain, Imaging, Stem cells
Peer reviewedyes

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