Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Microparticulate System for Antituberculosis Drug Delivery

last updated: 2019-01-21
ProjectNORTE45_3Bs - RL1 :: publications list
TitleDevelopment of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Microparticulate System for Antituberculosis Drug Delivery
Publication TypePapers in Scientific Journals
Year of Publication2018
AuthorsMiranda M. S., Rodrigues M. T., Domingues R. M. A., Costa R. R., Paz E., Rodríguez-Abreu C., Freitas P., Almeida B. G., Carvalho M. A., Gonçalves C., Ferreira C. M., Torrado E., Reis R. L., Pedrosa J., and Gomes M. E.
Abstract

Tuberculosis (TB) is an infectious disease which affects millions of people worldwide. Inhalable polymeric dry powders are promising alternatives as anti‐TB drug carriers to the alveoli milieu and infected macrophages, with potential to significantly improve the therapeutics efficiency. Here, the development of a magnetically responsive microparticulate system for pulmonary delivery of an anti‐TB drug candidate (P3) is reported. Microparticles (MPs) are developed based on a cast method using calcium carbonate sacrificial templates and incorporate superparamagnetic iron oxide nanoparticles to concentrate MPs in alveoli and enable drug on demand release upon actuation of an external alternate magnetic field (AMF). The MPs are shown to be suitable for P3 delivery to the lower airways and for alveolar macrophage phagocytosis. The developed MPs reveal unique and promising features to be used as an inhalable dry powder allowing the AMF control over dosage and frequency of drug delivery anticipating improved TB treatments.

JournalAdvanced Healthcare Materials
Volume7
Issue15
Pagination1800124
Date Published2018-05-23
PublisherWiley
ISSN2192-2640
DOI10.1002/adhm.201800124
URLhttps://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201800124
KeywordsBiomaterials, inhalable dry powders, magnetic drug targeting, Microparticulate systems, remotely controlled drug release
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

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