Biomaterials, Biodegradables and Biomimetics Research Group

Comunication - Oral

Modelling lung cancer metastasis through a human microcirculation on a chip

Abstract

Metastasis is a highly dynamic and multi-factorial process characterized by the escape of cancer cells from the primary tumor to a secondary site through the microvasculature. Lymphatic vessel remodeling in the tumor microenvironment has been shown to facilitate cancer spread through the lymphatic system and promote cancer dissemination. Although several microfluidicmodels have already been reported to study metastasis formation, most platforms focus merely on cell invasion through the blood vessels.[1],[2]

In this presentation, we will provide an overview of current microcirculation-on-a-chip models and highlight our current work in the development of a tumor-on-a-chip model, integrating both blood and lymphatic microvasculature. The model is currently being used to investigate the role of tumor-released mediators, particularly tumor derived extracellular vesicles, in lung cancer metastasis, as well as serving as a drug screening platform for the selection of the most adequate therapy. Overall, the designed platform will constitute a powerful platform to unravel the mechanisms that drive cancer cell intravasation and permit personalized medicine.


[1] Luque-González MA, Reis RL, Kundu SC, Caballero D, Adv. Biosys. 2000045, 2020

[2] Caballero D, Kaushik S, Correlo VM, Oliveira JM, Reis RL, Kundu SC, Biomaterials, 149, 98, 2017

Journal
3rd FoReCaST workshop
Keywords
drug screening, exosomes, In Vitro Model, microcirculation, Microfluidics, Organ-on-a-chip
Rights
Closed Access
Peer Reviewed
Yes
Status
published
Project
2MATCH
Year of Publication
2021
Date Published
2021-06-14
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