The Potential of Liquid Marbles for Biomedical Applications: A Critical Review

last updated: 2017-09-26
ProjectComplexiTE :: publications list
TitleThe Potential of Liquid Marbles for Biomedical Applications: A Critical Review
Publication TypePapers in Scientific Journals
Year of Publication2017
AuthorsOliveira N. M., Reis R. L., and Mano J. F.

Liquid marbles (LM) are freestanding droplets covered by micro/nanoparti- cles with hydrophobic/hydrophilic properties, which can be manipulated as a soft solid. The phenomenon that generates these soft structures is regarded as a different method to generate a superhydrophobic behavior in the liquid/ solid interface without modifying the surface. Several applications for the LM have been reported in very different fields, however the developments for bio- medical applications are very recent. At first, the LM properties are reviewed, namely shell structure, LM shape, evaporation, floatability and robustness. The different strategies for LM manipulation are also described, which make use of magnetic, electrostatic and gravitational forces, ultraviolet and infrared radiation, and approaches that induce LM self-propulsion. Then, very distinc- tive applications for LM in the biomedical field are presented, namely for diagnostic assays, cell culture, drug screening and cryopreservation of mam- malian cells. Finally, a critical outlook about the unexplored potential of LM for biomedical applications is presented, suggesting possible advances on this emergent scientific area. 

JournalAdvanced Healthcare Materials
Date Published2017-08-10
PublisherWiley Periodicals, Inc.
KeywordsBIOMEDICAL APPLICATIONS, Freestanding droplets, Liquid marbles, Soft solids
Peer reviewedyes

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