Rui Domingues has a multidisciplinary background in chemical engineering, material science, nanotechnology and tissue engineering.

His research focuses on the development of functional biomaterials for TERM applications, particularly exploring different nanostructured biomaterials for tendon tissue engineering and for studying cell behavior. His current researcher interests include application of molecular imprinting, biofabrication and organ-on-chip technologies for tendon regeneration and modelling.