Alternative methodology for chitin/hydroxyapatite composites using ionic liquids and supercritical fluid technology

last updated: 2013-09-16
TitleAlternative methodology for chitin/hydroxyapatite composites using ionic liquids and supercritical fluid technology
Publication TypePapers in Scientific Journals
Year of Publication2013
AuthorsSilva S. S., Duarte A. R. C., Dr. Oliveira J. M., Mano J. F., and Reis R. L.
Abstract

An alternative, green method was used to develop chitin-based biocomposite (ChHA) materials
by an integrated strategy using ionic liquids, supercritical fluid drying, and salt leaching. ChHA
matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt
and/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had
a heterogeneous porous microstructure with 65%–85% porosity and pore sizes in the range
of 100–300 µm. The hydroxyapatite was found to be well distributed within the composite
structures and had a positive effect in the viability and proliferation of osteoblast-like cells, in
vitro. Our findings indicate that these ChHA matrices have potential applications in bone tissue
engineering.

JournalJournal of Bioactive and Compatible Polymers
Volume28
Issue5
Pagination481-491
Date Published2013-08-27
PublisherSage
DOI10.1177/0883911513501595
URLhttp://jbc.sagepub.com/content/28/5/481
Keywordschitin, hydroxyapatite, ionic liquids, supercritical fluid technology
RightsopenAccess
Peer reviewedyes
Statuspublished

Back to top