Beta-PVDF membranes induce cellular proliferation and differentiation in static and dynamic conditions

last updated: 2017-03-07
TitleBeta-PVDF membranes induce cellular proliferation and differentiation in static and dynamic conditions
Publication TypePapers in Scientific Journals
Year of Publication2008
AuthorsRodrigues M. T., Gomes M. E., Mano J. F., and Reis R. L.

Bone marrow cells are a potential source to induce different lineage cells which can be
used to rebuild or replace damaged tissues using a Tissue Engineering (TE) approach. However, TE
strategies usually require the use of a material to support the development of a biological tissue.
Beta-polyvinylidene fluoride (β-PVDF) is a biocompatible, thermoplastic with piezo-electrical
properties that has been shown to provide a good cellular attachment and therefore might present
advantageous properties as a scaffold material for cell seeding/culturing. The present study
describes the characterization of β-PVDF membranes as a support material for growth and
differentiation of goat marrow cells (GMCs) into osteoblasts, leading to the formation of substitutes
for tissue regeneration.
The obtained results suggest that β-PVDF piezoelectric properties influence cellular behavior. β-
PVDF membranes not only enhance GMCs adherence and proliferation but also improve
differentiation towards the osteogenic phenotype both in static and dynamic culture conditions.
Furthermore, β-PVDF membranes exhibit very promising properties, suggesting that this material
provides adequate support for the seeding and the development of undifferentiated cells towards a
desired phenotype.

JournalMaterials Science Forum 2008
Date Published2008-06-13
Keywordscell differentiation, cell proliferation, marrow stromall cells, membranes, piezo-electric, PVDF
Peer reviewedno

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