Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Biocompatible polymeric microparticles produced by a simple biomimetic approach

Abstract

The use of superhydrophobic surfaces to produce polymeric particles proves to be biologically friendly since it entails the pipetting and subsequent cross-linking of polymeric solutions under mild experimental conditions. Moreover, it renders encapsulation efficiencies of ∼100%. However, the obtained particles are 1 to 2 mm in size, hindering to a large extent their application in clinical trials. Improving on this technique, we propose the fabrication of polymeric microparticles by spraying a hydrogel precursor over superhydrophobic surfaces followed by photo-cross-linking. The particles were produced from methacrylamide chitosan (MA-CH) and characterized in terms of their size and morphology. As demonstrated by optical and fluorescence microscopy, spraying followed by photo-cross-linking led, for the first time, to the production of spherical particles with diameters on the order of micrometers, nominal sizes not attainable by pipetting. Particles such as these are suitable for medical applications such as drug delivery and tissue engineering.

Journal
Langmuir
Volume
30
Issue
16
Pagination
4535–4539
Publisher
ACS publications
URL
http://pubs.acs.org/doi/abs/10.1021/la500286v
Keywords
Biomaterials, Methacrylated Chitosan, microparticles, superhydrophobic surfaces
Rights
Open Access
Peer Reviewed
Yes
Status
published
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