Biomaterials, Biodegradables and Biomimetics Research Group

Book Chapter

Bioengineered Strategies for Tendon Regeneration

Abstract

Their important mechanical function predisposes tendons to injury and rupture, becoming a worldwide
clinical problem. Commonly injured tendons include the rotator cuff, finger flexors, patellar, and
Achilles tendon [1]. As poor cellular and vascular tissues [2], tendons present some healing constraints,
typically requiring surgical intervention. Available reparative surgeries rely on tissue replacement with
auto- or allografts [3], which are often accompanied with donor site morbidity, pain, inferior functionalities,
and eventually graft failure.
Due to the market demand, commercial substitutes for tendon repair have been developed as biological
and synthetic scaffolds.

Journal
In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design
Pagination
275-294
Publisher
Academic Press
ISBN
978-0-12-802225-2
URL
http://www.sciencedirect.com/science/article/pii/B9780128022252000155
Keywords
Biomaterials Mechanical stimulation, Tendon Tendon substitutes, Tendon tissue engineering strategies, Tenogenic differentiation
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
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