Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Biomimetic apatite deposition on polymeric microspheres treated with a calcium silicate solution

Abstract

Bioactive polymeric microspheres can be prepared by means of coating them with a calcium silicate solution and subsequently soaking in a simulated body fluid (SBF). Such combination should allow for the development of bioactive microspheres for several applications in the medical field including tissue engineering carriers. Four types of polymeric microspheres, with different sizes, were used in this work: (i) ethylene-vinyl alcohol copolymer (20-30 mu m), (ii) polyamide 12 with 10% magnetite (100 mu m), (iii) polyamide 12 (10-30 mu m) and (iv) polyamide 12 (300 mu m). These microspheres were soaked in a calcium silicate solution at 36.5 degrees C for various periods of time under different conditions. Afterwards, they were dried in air at 60 and 100 degrees C for 24 hr. Then, the samples were soaked in SBF for 1, 3, and 7 days. Fourier transformed infrared spectroscopy, thin-film X-ray diffraction, and scanning electron microscopy showed that after the calcium silicate treatment and the subsequent soaking in SBF, the microspheres successfully formed an apatite layer on their surfaces in SBF within 7 days due to the formation of silanol groups, which are effective for apatite formation. (C) 2009, Wiley Periodicals, Inc. J Bionted Mater Res Part B: Appl Biontater 91B: 239-247, 2009

Journal
Journal of Biomedical Materials Research part B
Volume
91B
Issue
1
Pagination
239-247
Publisher
Wiley Periodicals, Inc. J
ISSN
1552-4973
URL
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31395/abstract
Keywords
Biomimetics, Calcium silicate, polymeric microspheres, silanol (Si-OH), sol-gel processes
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Year of Publication
2009
DOI
10.1002/jbm.b.31395
Date Published
2009-05-13
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