Biomaterials, Biodegradables and Biomimetics Research Group

Conference Abstract -ISI Web of Science Indexed

Chitosan - Alginate multilayered films with gradients of physical cues

Abstract

In general cell types are sensitive to mechanical stimulus of the surrounding environment which affects several cell properties. Thus, the development of biocompatible coatings with tuned mechanical properties are a current challenge, since gradients of physical signals are often applied in cellular processes to reconstruct the complex anisotropic environment presented by extracellular matrix (ECM) (1,2). Layer-by-layer (LbL) appears as a powerful tool since it allows the development of biomimetic multilayer films with well–controlled structures at both the nano and micro-scales (2). This study aimed to develop chitosan (CHIT) and alginate (ALG) polyelectrolyte multilayers with gradients of physical cues generated by changing the reaction time of
genipin crosslinking as a function of controlled distance.

Journal
Journal of Tissue Engineering and Regenerative Medicine
Volume
8
Pagination
509
ISSN
1932-6254
URL
http://onlinelibrary.wiley.com/doi/10.1002/term.1932/pdf
Keywords
gradients, LbL multilayer assemblies
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
N/A
Year of Publication
2014
Date Published
2014-06-10
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