Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Chitosan/chondroitin sulfate multilayers as supports for calcium phosphate biomineralization

Abstract

We investigated the interaction of natural derived macromolecular multilayers with calcium and phosphate ions entirely processed using the layer-by-layer (LbL) technique. A nanostructured multilayer component, with 5 or 10 bilayers, was first produced using weak polyelectrolyte biopolymers, chitosan and chondroitin sulfate. This was followed by sequential passing of solutions containing Ca2+ and PO43− over the multilayers. QCM-D, SEM and EDX results conferred the formation of calcium phosphate (CaP) over the polyelectrolyte multilayers. Initiation of precipitation was observed earlier in the 10 bilayers coating than in the 5 bilayers one. These results indicate the potential of multilayers to trap ions, as a biomimetic approach that can be used to induce CaP precipitation. This could enable the preparation of more performant bioactive composite biomaterials for orthopedic applications, including in bone tissue engineering.

Journal
Materials Letters
Volume
121
Pagination
62-65
Publisher
Elsevier
ISSN
0167-577X
URL
http://dx.doi.org/10.1016/j.matlet.2014.01.099
Keywords
Biomaterials, Biomimetic, Multilayer structure, nanocomposites
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
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