Chitosan/chondroitin sulfate multilayers as supports for calcium phosphate biomineralization

last updated: 2014-02-26
TitleChitosan/chondroitin sulfate multilayers as supports for calcium phosphate biomineralization
Publication TypePapers in Scientific Journals
Year of Publication2014
AuthorsLeite A. J., Sher P., and Mano J. F.

We investigated the interaction of natural derived macromolecular multilayers with calcium and phosphate ions entirely processed using the layer-by-layer (LbL) technique. A nanostructured multilayer component, with 5 or 10 bilayers, was first produced using weak polyelectrolyte biopolymers, chitosan and chondroitin sulfate. This was followed by sequential passing of solutions containing Ca2+ and PO43− over the multilayers. QCM-D, SEM and EDX results conferred the formation of calcium phosphate (CaP) over the polyelectrolyte multilayers. Initiation of precipitation was observed earlier in the 10 bilayers coating than in the 5 bilayers one. These results indicate the potential of multilayers to trap ions, as a biomimetic approach that can be used to induce CaP precipitation. This could enable the preparation of more performant bioactive composite biomaterials for orthopedic applications, including in bone tissue engineering.

JournalMaterials Letters
Date Published2014-04-15
KeywordsBiomaterials, Biomimetic, Multilayer structure, nanocomposites
Peer reviewedyes

Back to top