Combined application of Silk-fibroin/methacrylated gellan gum hydrogel in tissue engineering approaches for partial and/or total meniscus replacement while enabling control of neovascularisation

last updated: 2014-04-15
TitleCombined application of Silk-fibroin/methacrylated gellan gum hydrogel in tissue engineering approaches for partial and/or total meniscus replacement while enabling control of neovascularisation
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2013
AuthorsPereira H., Silva-Correia J., Yan L. P., Oliveira A. L., Dr. Oliveira J. M., Espregueira-Mendes J. D., and Reis R. L.
Abstract

Meniscus tissue engineering can benefit from the use of highly developed scaffolds that are able to mimic the anatomy of this complex tissue, i.e. enable controlling the segmental vascularization during tissue regeneration. In this work, novel scaffolds were produced combining a porous silk polymeric matrix at 12 wt% (silk-12) and the methacrylated gellan gum hydrogel (iGG-MA), which was previously shown to be non-angiogenic. A chorioallantoic membrane (CAM) assay was used to investigate the ability of the silk-12/iGG-MA scaffolds to control cell ingrowth, segmental vascularization, and innervations.

JournalRevue de Chirurgie Orthopédique et Traumatologique
Conference NameTravaux de la Société Française d'Arthroscopie
Volume99
Issue8
Paginatione18-e19
Date Published2013-12-01
Keywordsmeniscus, Silk Fibroin
RightsopenAccess
Peer reviewedyes
Statuspublished

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