Biomaterials, Biodegradables and Biomimetics Research Group

Conference Abstract -ISI Web of Science Indexed

Combined application of Silk-fibroin/methacrylated gellan gum hydrogel in tissue engineering approaches for partial and/or total meniscus replacement while enabling control of neovascularisation

Abstract

Meniscus tissue engineering can benefit from the use of highly developed scaffolds that are able to mimic the anatomy of this complex tissue, i.e. enable controlling the segmental vascularization during tissue regeneration. In this work, novel scaffolds were produced combining a porous silk polymeric matrix at 12 wt% (silk-12) and the methacrylated gellan gum hydrogel (iGG-MA), which was previously shown to be non-angiogenic. A chorioallantoic membrane (CAM) assay was used to investigate the ability of the silk-12/iGG-MA scaffolds to control cell ingrowth, segmental vascularization, and innervations.

Journal
Revue de Chirurgie Orthopédique et Traumatologique
Volume
99
Issue
8
Pagination
e18-e19
Keywords
meniscus, Silk Fibroin
Rights
Open Access
Peer Reviewed
Yes
Status
published
Year of Publication
2013
Date Published
2013-12-01
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