Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology

Abstract

Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-e-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and microcomputed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.

Journal
International Journal of Pharmaceutics
Volume
492
Issue
1-2
Pagination
73-79
Publisher
PubMed Commons
ISSN
0378-5173
URL
www.ncbi.nlm.nih.gov/pubmed/26142248
Keywords
Biodegradable polymers, Drug delivery systems, Ibuprofen, Supercritical carbon dioxide, Therapeutic deep eutectic solvents
Rights
Open Access
Peer Reviewed
Yes
Status
published
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