Evaluating Biomaterial-and Microfluidic-Based 3D Tumor Models

last updated: 2016-02-01
ProjectArticulate :: publications list
TitleEvaluating Biomaterial-and Microfluidic-Based 3D Tumor Models
Publication TypeReview Paper
Year of Publication2015
AuthorsCarvalho M. R., Daniela L., Reis R. L., Correlo V. M., and Dr. Oliveira J. M.
Abstract Text

Cancer is a major cause of morbidity and mortality worldwide, with a disease burden estimated to increase in the coming decades. Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail to address. We review the current "state-of-the-art" in 3D Tissue Engineering (TE) models developed for and used in cancer research. Scaffold-based TE models and microfluidics, are assessed for their potential to fill the gap between 2D models and clinical application. Recent advances in combining the principles of 3D TE models and microfluidics are discussed, with a special focus on biomaterials and the most promising chip-based 3D models.

JournalTrends in Biotechnology
Volume33
Issue11
Pagination667–678
Date Published2015-10-23
PublisherElsevier
ISSN0167-7799
DOI10.1016/j.tibtech.2015.09.009
URLhttp://www.sciencedirect.com/science/article/pii/S016777991500195X
KeywordsBiomaterials, cancer microenvironment, drug discovery, Microfluidics
RightsopenAccess
Peer reviewedyes
Statuspublished

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