Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Gelatin Porous Scaffolds Fabricated by a Simple Gas Foaming Technique: Characterisation and Cytotoxicity Assessment

Abstract

The current study presents an effective and simple strategy to obtain stable porous scaffolds from gelatin via a gas foaming method. The technique exploits the intrinsic foaming ability of gelatin in the presence of CO2 to obtain a porous structure stabilised with glutaraldehyde. The produced scaffolds were characterised using physical and mechanical characterisation methods. The results showed that gas foaming may allow the tailoring of the 3-dimensional structure of the scaffolds with an interconnected porous structure. To assess the effectiveness of the preparation method in mitigating the potential cytotoxicity risk of using glutaraldehyde as a crosslinker, direct and in-direct cytotoxicity assays were performed at different concentrations of glutaraldehyde. The results indicate the potential of the gas foaming method, in the preparation of viable tissue engineering scaffolds.

Journal
Materials Science and Engineering: C
Volume
48
Pagination
63-70
URL
http://www.sciencedirect.com/science/article/pii/S0928493114006948
Keywords
crosslinking, Denaturation temperature, Gas foaming, Gelatin, Tensile strength
Rights
Closed Access
Peer Reviewed
Yes
Status
published
Year of Publication
2014
Date Published
2014-11-11
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