Biomaterials, Biodegradables and Biomimetics Research Group

Book Chapter

Lessons from the Sea: Distribution, SAR and Molecular Mechanisms of Anti-inflammatory Drugs from Marine Organisms

Abstract

Marine organisms have been increasingly regarded as excellent sources of new drugs for human therapeutics due to their remarkable chemistry, which in turn is reflected in their wide range of biological applications, including cancer, inflammation, infection and pain. In the last 20 years several new drugs have been discovered, some of them with novel pharmacological targets and the first sea-derived approved medicines are now paving their way into the market. In this review we will focus in small-molecule drugs obtained from marine animals (sponges, gorgonians, mollusks, echinoderms) for the treatment of inflammation. The distribution of these compounds by different taxonomical families will be discussed, as well as the state-of the-art regarding their structure-activity relationship. The most important chemical classes will be presented, such as terpenes, alkaloids, among others. The most important molecular targets, including phospholipase A2 (PLA2), cyclooxygenases (COX), nitric oxide synthase (NOS) and NF-κB will be discussed.

Journal
Studies in Natural Products Chemistry (Bioactive Natural Products)
Volume
40
Publisher
Elsevier Science Publishers
Keywords
Anti-inflammatory, drugs, marine
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Year of Publication
2013
Date Published
2013-09-12
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