Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

Light responsive multilayer surfaces with controlled spatial extinction capability

Abstract

Multilayer systems obtained using the Layer-by-Layer (LbL) technology have been proposed for a variety of biomedical applications in tissue engineering and regenerative medicine. LbL assembly is a simple and highly versatile method to modify surfaces and fabricate robust and highly-ordered nanostructured coatings over almost any type of substrates and with a wide range of substances. The incorporation of polyoxometalate (POM) inorganic salts as constituents of the layers presents a possibility of promoting light-stimuli responses in LbL substrates. We propose the design of a biocompatible photo-responsive multilayer system based on a Preyssler-type POM ([NaP5W30O110]14−) and a natural origin polymer, chitosan, using the LbL methodology. The photo-reduction properties of the POM allow the spatially controlled disruption of the assembled layers due to the weakening of the electrostatic interactions between the layers. This system has found applicability in detaching devices, such as the cell sheet technology, which may solve the drawbacks actually found in other cell treatment proposals.

Journal
J. Mater. Chem. B
Volume
4
Pagination
1398-1404
Publisher
Royal Society of Chemistry (RSC)
ISSN
2050-7518
URL
http://pubs.rsc.org/en/content/articlepdf/2016/tb/c5tb02606g
Keywords
Cell Sheet, Free-standing membrane, layer-by-layer, Light stimuli, natural origin polymers, Polyoxometalates
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
RL1 - ABMR
Year of Publication
2016
DOI
10.1039/C5TB02606G
Date Published
2016-01-19
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