Biomaterials, Biodegradables and Biomimetics Research Group

Conference Abstract -ISI Web of Science Indexed

Magnetic cells with surface modified Fe3O4 spherical and rod-shaped nanoparticles for tissue engineering and regenerative medicine applications

Abstract

Although magnetic nanoparticles (MNPs) have fueled the field of nanotechnology in the last few years, the application of MNPs in cell-based therapies has seldom been considered. We hypothesized that magnetically labeled cells could be delivered by intravenous injection, and guided to sites of injury within the body, upon magnetic actuation. Moreover, cells could be retained in the damaged site, creating three dimensional tissue constructs that mimic the structure and functional properties of the native tissue. In this work cells were loaded with superparamagnetic Fe3O4 sphere or rod-shaped nanoparticles. The influence of MNPs shape, size, concentration, and time of incubation on cellular internalization was analyzed. Additionally, cell-sheets were successfully generated by magnetic force-based tissue engineering (TE).

Journal
Journal of Tissue Engineering and Regenerative Medicine
Volume
8
Pagination
49-50
Publisher
Journal of Tissue Engineering and Regenerative Medicine
Keywords
Magnetic nanoparticles, Smart responsive systems, Targeted cell delivery, Three dimensional (3D) cell culture, tissue engineering.
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
SupraRelax
Year of Publication
2014
Date Published
2014-06-11
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