The success of bone tissue engineering (TE) strategies is strongly dependent on the development of new synthetic materials com- bining osteoconductive, osteoinductive and osteogenic properties. Recent studies suggest that biomaterials incorporating silanol groups promote and maintain osteogenesis with or without bio- logical stimuli. This study aims to evaluate the osteoconductivity and osteogenic properties of novel wet-spun fibre mesh scaffolds of SPCL (blend of starch with polycaprolactone) with or without superficial functionalized silanol (Si-OH) groups by seeding/culturing them with goat marrow stromal cells (GBMCs)