Biomaterials, Biodegradables and Biomimetics Research Group

Conference Abstract -ISI Web of Science Indexed

Tenogenic potential of human stem cells from the amniotic fluid and adipose tissue

Abstract

Tendons are highly prone to injury and the intrinsic hypocellularity and hypovascularity make their natural healing extremely slow and inefficient when severed damaged. Surgical repair with grafts is common but unsuccessful in a long term basis. The development of tissue engineering strategies based on stem cells explores a natural endogenous system of regeneration with potential for tendon application. We propose to establish biochemical culturing conditions to assess the tenogenic potential of human adipose stem cells (hASCs) and amniotic fluid-derived stem cells (hAFSCs), known for their proliferative and differentiation capacities. Since several growth factors (GFs) participate in tendon formation and ECM synthesis, these GFs were added to the culture medium to stimulate tenogenic differentiation of these cells. This study also envisions the application of hASCs and/or hAFSCs in cell-based strategies for tendon repair.

Journal
Journal of Tissue Engineering and Regenerative Medicine
Volume
6
Pagination
30-30
Keywords
growth factors, Human adipose stem cells, Human amniotic fluid-derived stem cells, Tendon
Rights
Open Access
Peer Reviewed
Yes
Status
published
Year of Publication
2012
Date Published
2012-10-12
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