Understanding cellular behaviour in early and late stage of MSD

last updated: 2014-11-07
ProjectMultiScaleHuman :: publications list
TitleUnderstanding cellular behaviour in early and late stage of MSD
Publication TypeConference Abstract -ISI Web of Science Indexed
Year of Publication2014
AuthorsOndrésik, M., Correia C., Sousa, R.A., Oliveira J. M., and Reis R. L.

Osteoarthritis (OA) is the most common joint disease worldwide with only limited treatment options1. It is believed that the thorough analyses of the disease on cellular and molecular base can lead us to the discovery of new targets, and to the development of new therapies. Thus, we have been working on the development of a 3D model of human OA knee cartilage. By this in vitro model, it is expected to gain a better understanding on the disease process. The two main aspects of our research are: (1) how the mechanical loading and (2) how the presence of pro-inflammatory cytokines, e.g. TNF-α and IL1-β affects the degenerative processes2,3. In the present study, we demonstrated the effect of the different cytokines on monolayer and tissue culture. 

JournalJournal of Tissue Engineering and Regenerative Medicine
Conference NameTERMIS - EU 2014
Date Published2014-06-09
Conference LocationGenoa, Italy
Keywordscartilage, Osteoarthritis
Peer reviewedno

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