In vivo Behaviour of BonelikeÒ/PLGA Hybrid: Histological Analysis and Peripheral Quantitative Computed Tomography (pQ-CT) Evaluation

last updated: 2013-02-16
TitleIn vivo Behaviour of BonelikeÒ/PLGA Hybrid: Histological Analysis and Peripheral Quantitative Computed Tomography (pQ-CT) Evaluation
Publication TypeConference Paper -ISI Web of Science Indexed
Year of Publication2007
AuthorsDr. Oliveira J. M., Lopes M. A., Kawai T., Ohtsuki C., Santos J., and Afonso A.
Abstract

The present work consisted in assessing the in vivo biological behaviour of novel Bonelike/PLGA hybrid materials through subcutaneous and tibiae implantations for a 4 week period using an animal model. No sign of inflammation was observed as a result of subcutaneous implantation, which reveals that these materials were well-tolerated by the soft tissues. pQ-CT analysis demonstrated that the implanted materials were highly osteointegrated in bone tissue. SEM analysis at bone defect area revealed that Bonelike resorption occurred after 4 weeks of implantation. Although the osteoconductive properties of Bonelike have been reported in literature, the present work allowed to demonstrate that the silane-coupling agent and the PLGA treatments do not significantly modify the biological performance of Bonelike. This result is strongly encouraging since Bonelike/PLGA hybrid materials are being developed for bone tissue healing/regeneration purposes with simultaneous delivery of therapeuthic molecules.

Journal Key Engineering Materials Vols. 254-256
Pagination 565-568
Date Published2007-03-16
PublisherTrans Tech Publications Ltd.
KeywordsBonelike, PQCT
RightsopenAccess
Peer reviewedyes
Statuspublished

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