Biomaterials, Biodegradables and Biomimetics Research Group

Papers in Scientific Journals

3D segmentation of intervertebral discs: From concept to the fabrication of patient-specific scaffolds

Abstract

Aim: To develop a methodology for producing patient-specific scaffolds that mimic the annulus fibrosus (AF) of the human intervertebral disc (IVD) by means of combining magnetic resonance imaging (MRI) and 3D bioprinting.

Methods: In order to obtain the AF 3D model from patient’s volumetric MRI dataset, the RheumaSCORE segmentation software was used. Polycaprolactone scaffolds with three different internal architectures were fabricated by 3D bioprinting, and characterized by micro-computed tomography.

Results: The demonstrated methodology of a geometry reconstruction pipeline enabled to successfully obtain an accurate AF model and 3D print patient-specific scaffolds with different internal architectures.

Conclusion: The results guide us towards patient-specific IVD tissue engineering as demonstrated a way of manufacturing personalized scaffolds using patient’s MRI data.

Journal
Journal of 3D Printing in Medicine
Volume
1
Issue
2
Pagination
91-101
Publisher
Future Medicine
ISSN
2059-4755
URL
http://www.futuremedicine.com/doi/abs/10.2217/3dp-2016-0011
Keywords
3D bioprinting, intervertebral disc, MRI segmentation, patient-specific approach, Rapid prototyping, Reverse Engineering, Tissue engineering
Rights
Restricted Access
Peer Reviewed
Yes
Status
published
Project
EPIDisc
Year of Publication
2017
DOI
10.2217/3dp-2016-0011
Date Published
2017-03-03
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