Adaptable hydrogel with reversible linkages for regenerative medicine: Dynamic mechanical microenvironment for cells

last updated: 2020-11-12
Project IF/01285/2015 :: publications list
TitleAdaptable hydrogel with reversible linkages for regenerative medicine: Dynamic mechanical microenvironment for cells
Publication TypeReview Paper
Year of Publication2021
AuthorsTong Z., Jin L., Dr. Oliveira J. M., Reis R. L., Zhong Q., Mao Z., and Gao C.
Abstract Text

Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular matrix. These materials are starting to play important roles in regenerative medicine because of their similarities to native matrix in water content and flexibility. It would be very advantagoues for researchers to be able to regulate cell behavior and fate with specific hydrogels that have tunable mechanical properties as biophysical cues. Recent developments in dynamic chemistry have yielded designs of adaptable hydrogels that mimic dynamic nature of extracellular matrix. The current review provides a comprehensive overview for adaptable hydrogel in regenerative medicine as follows. First, we outline strategies to design adaptable hydrogel network with reversible linkages according to previous findings in supramolecular chemistry and dynamic covalent chemistry. Next, we describe the mechanism of dynamic mechanical microenvironment influence cell behaviors and fate, including how stress relaxation influences on cell behavior and how mechanosignals regulate matrix remodeling. Finally, we highlight techniques such as bioprinting which utilize adaptable hydrogel in regenerative medicine. We conclude by discussing the limitations and challenges for adaptable hydrogel, and we present perspectives for future studies.

JournalBioactive Materials
Volume6
Issue5
Pagination1375-1387
Date Published2021-05-01
PublisherKeAi
ISSN2452-199X
DOI10.1016/j.bioactmat.2020.10.029
URLhttps://doi.org/10.1016/j.bioactmat.2020.10.029
KeywordsAdaptable hydrogel, Dynamic covalent chemistry, Dynamic mechanical microenvironment, Supramolecular Chemistry, Yes-associated protein
RightsopenAccess
Peer reviewedyes
Statuspublished

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