Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine

last updated: 2021-04-16
ProjectFROnTHERA :: publications list
TitleAdvances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine
Publication TypeReview Paper
Year of Publication2021
AuthorsFernandes D. C., Reis R. L., and Dr. Oliveira J. M.
EditorsCarney S.
Abstract Text

Clinical trials continue to fall short regarding drugs to effectively treat brain-affecting diseases. Althoughthere are many causes of these shortcomings, the most relevant are the inability of most therapeuticagents to cross the blood–brain barrier (BBB) and the failure to translate effects from animal models topatients. In this review, we analyze the most recent developments in BBB, neural, and neurovascularmodels, analyzing their impact on the drug development process by considering their quantitative andphenotypical characterization. We offer a perspective of the state-of-the-art of the models that couldrevolutionize the pharmaceutical industry.

JournalDrug Discovery Today
Volume26
Issue3
Pagination754-768
Date Published2021-03-01
PublisherElsevier
ISSN1741-8364
DOI10.1016/j.drudis.2020.11.009
URLhttps://www.sciencedirect.com/science/article/pii/S1359644620304748
Keywords3D neural models, drug screening, regenerative medicine
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

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