Biocompatible ionic liquids (Bio-ILs) are an eco- and bio-friendly family of ionic liquids (ILs) useful in
applications ranging from the electrochemical to the biomedical fields. The most promising strategies
for their synthesis involve using molecules from bio-renewable sources as a basis for both the anionic
and cationic counterparts of the Bio-ILs structure. Several studies have been conducted on Bio-IL
properties, including their impact on the environment and health safety. Herein, we review progress and
strategies towards the synthesis of Bio-ILs and address their ecotoxicological and biological impact.
Furthermore, we discuss the impact of using these compounds in a diverse range of applications, with
some insights toward their use in the development of improved technologies.