Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

last updated: 2020-04-15
ProjectSmarTendon :: publications list
TitleBiomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior
Publication TypeReview Paper
Year of Publication2020
AuthorsTeixeira S. P. B., Domingues R. M. A., Shevchuk M., Gomes M. E., Peppas N. A., and Reis R. L.
Abstract Text
Growth factors (GFs) are proteins secreted by cells that regulate a variety
of biological processes. Although they have long been proposed as potent
therapeutic agents, their administration in a soluble form has proven costly
and ineffective due to their short half-lives in biological environments.
Biomaterial-based approaches are increasingly sought as alternatives to
improve the efficacy or, ideally, replace the need for exogenous administration
of GFs in regenerative medicine strategies. The means by which these systems
evolve from biomaterials for conventional controlled release of GFs to the
recent extracellular matrix (ECM)–inspired approaches for sequestering these
labile molecules and regulating their spatiotemporal activity and presenta-
tion are reviewed. Focus is placed on biomaterials functionalized either with
ECM components, which show promiscuous GF binding, or with targeted GF
ligands (antibodies, aptamers, or peptides). The potential of synthetic plat-
forms with abiotic affinity as cost-effective alternatives to the current biological
ligands is also discussed. Overall, the various GF sequestering systems devel-
oped so far have remarkably improved the activity of GFs at reduced doses
and, in some cases, completely avoided the need for their exogenous adminis-
tration to guide cell fates. These bioinspired concepts thus enable the rational
exploration of the full therapeutic potential of GFs in regenerative medicine.
JournalAdvanced Functional Materials
Date Published2020-03-12
KeywordsBiomaterials, growth factors
Peer reviewedyes

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