Biopolymers and Polymers in the Search of Alternative Treatments for Meniscal Regeneration: State of the Art and Future Trends

last updated: 2018-04-27
Project IF/01285/2015 :: publications list
TitleBiopolymers and Polymers in the Search of Alternative Treatments for Meniscal Regeneration: State of the Art and Future Trends
Publication TypeReview Paper
Year of Publication2018
AuthorsMurphy C. A., Costa J. B., Silva-Correia J., Dr. Oliveira J. M., Reis R. L., and Collins M. N.
Abstract Text

This review focuses on the meniscus and the biomaterials involved in meniscal repair and regeneration. Clinical issues associated with the meniscus are introduced and treatment strategies are discussed in terms of biomaterial choice: extracellular matrix materials (ECM), natural materials (ECM-like), synthetic or hybrids of these. These material choices lead to a myriad of options ranging from permanent implants to biodegradable scaffolds (with and without cells, binding ligands and growth factors). The latest chemistries behind emerging candidate materials are discussed in terms of functional modifications, crosslinking agents and techniques. Finally, we review the latest and promising advances associated with bioprinted meniscal implants and the drive towards more functional bioinks with the overall goal of achieving a patient-specific meniscal implant.

JournalApplied Materials Today
Volume12
Issue2018
Pagination51-71
Date Published2018-04-06
PublisherElsevier
ISSN2352-9407
DOI10.1016/j.apmt.2018.04.002
URLhttps://www.sciencedirect.com/science/article/pii/S2352940718301410
KeywordsBioprinting, meniscus, regenerative medicine, Tissue engineering
RightsrestrictedAccess
Peer reviewedyes
Statuspublished

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