Blood derivatives awaken in regenerative medicine strategies to modulate wound healing

last updated: 2019-01-25
ProjectTERM - Programa de Doutoramento FCT :: publications list
TitleBlood derivatives awaken in regenerative medicine strategies to modulate wound healing
Publication TypeInvited Review Paper
2018
Mendes B. B., Gómez-Florit M., Babo P. S., Domingues R. M. A., Reis R. L., and Gomes M. E.
Ghandehari H.
Abstract

Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awakened as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms. Herein, we highlight recent trends on the use biomaterials to protect, sequester and deliver these pools of biomolecules in tissue engineering and regenerative medicine approaches. Particular emphasis is given to strategies that enable to control their spatiotemporal delivery and improve the selectivity of presentation profiles of the biomolecules derived from blood derivatives rich in platelets. Finally, we discussed possible directions for biomaterials design to potentiate the aimed regenerative effects of blood derivatives and achieve efficient therapies.

Journal TitleScar Wars
Volume129
Pagination376-393
Date Published2018-04-18
PublisherElsevier
ISSN0169-409X
DOI10.1016/j.addr.2017.12.018
URLhttps://linkinghub.elsevier.com/retrieve/pii/S0169-409X(17)30321-6
KeywordsBiomaterials, Blood derivatives, DELIVERY, platelet, regenerative medicine, Tissue engineering, Wound healing
RightsopenAccess
Peer reviewedyes
Statuspublished

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