Glycosylation of proteins is a common post-translational modification by which glycans of different complexity are grafted onto the protein core. Glycosylation is involved in the regulation of different cellular processes, such as adhesion, differentiation and proliferation, or activation of pathologic pathways. In fact, a modified glycosylation patterns (e.g. truncation) have been associated with neurodegeneration, inflammation, auto-immune activity and cancer.