Designing microenvironments for optimal outcomes in tissue engineering and regenerative medicine: From biopolymers to culturing conditions

last updated: 2020-04-11
ProjectMagTT :: publications list
TitleDesigning microenvironments for optimal outcomes in tissue engineering and regenerative medicine: From biopolymers to culturing conditions
Publication TypeBook Chapter
Year of Publication2019
AuthorsTsiapalis D., Ribeiro S., De Pieri A., Sallent I., Guillaumin S., Gaspar D., Korntner S., Bayon Y., Gomes M. E., Reis R. L., and Zeugolis D. I.
EditorsReis R. L., and Gomes M. E.
Abstract Text

Bone marrow mesenchymal stem cells have been extensively used for tissue engineering and regenerative medicine applications due to their ease of isolation and expansion and their ability to differentiate towards various lineages of mesodermal origin. Despite these properties, their clinical potential is often hampered by the simplicity of the in vitro environment and its inability to resemble the complex in vivo niche. Herein, different microenvironmental cues (e.g. surface topography, substrate stiffness, mechanical stimulation, oxygen tension and co-culture systems) that have been utilised to enhance the therapeutic efficacy of bone marrow mesenchymal stem cells are discussed.

Book TitleEncyclopedia of Tissue Engineering and Regenerative Medicine
Pagination119-30
Date2019-06-03
PublisherAcademic Press
ISBN 9780128136997
URLhttps://www.elsevier.com/books/encyclopedia-of-tissue-engineering-and-regenerative-medicine/reis/978-0-12-813699-7
KeywordsMicroenvironmental cues, Surface topography, Tissue engineering
RightsopenAccess
Peer reviewedyes
Statuspublished

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